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Am. J. Respir. Cell Mol. Biol., Vol 12, No. 5, May 1995, 455-460.

The role of growth factors and cytokines in the tumorigenesis and immunobiology of malignant mesothelioma

DR Fitzpatrick, DJ Peroni and H Bielefeldt-Ohmann
Transplantation Biology Unit, Queensland Institute of Medical Research, Herston, Australia.

Malignant mesothelioma (MM) is an asbestos-associated cancer that is increasing in incidence worldwide and is refractory to conventional therapy. MM cells are potent sources of a number of cytokines, some of which have recently been shown to be directly involved in the aggressive growth and spread of MM tumors. Emerging data also suggest involvement of MM-derived cytokines in systemic paraneoplastic syndromes including immunosuppression, thrombocytosis, cachexia, amyloidosis, and hypoglycemia. Additional characterization of the expression of cytokines and cytokine receptors in situ in MM tumors may provide a more complete picture of the autocrine and paracrine processes which occur in MM. Improved therapy of MM, particularly cytokine-based approaches, is likely to benefit from further elucidation of the patterns and regulation of cytokine expression associated with MM tumors.


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