help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blyth, D. I.
Right arrow Articles by Sanjar, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blyth, D. I.
Right arrow Articles by Sanjar, S.

Am. J. Respir. Cell Mol. Biol., Volume 19, Number 1, July, 1998 38-54

Induction, Duration, and Resolution of Airway Goblet Cell Hyperplasia in a Murine Model of Atopic Asthma: Effect of Concurrent Infection with Respiratory Syncytial Virus and Response to Dexamethasone

David I. Blyth, Michael S. Pedrick, Tony J. Savage, Helen Bright, Julian E. Beesley, and Shahin Sanjar

Respiratory Diseases, Molecular Pathology and Systems Biology Units, Glaxo Wellcome Research and Development, Stevenage, Hertfordshire, United Kingdom

We recently described a murine model of atopic asthma in which a marked, extensive hyperplasia of airway goblet cells is induced by repeated challenge of ovalbumin (OA)-sensitized mice with intratracheally administered allergen (Am. J. Respir. Cell Mol. Biol. 1996;14:425-438). We report here the time course of the duration of this feature and of its spontaneous resolution in the absence of further allergen exposure. Induction of severe neutrophilic inflammation in the airways by repeated intratracheal administration of lipopolysaccharide failed to induce goblet cell hyperplasia (GCH) to as great a degree as that induced by allergen, suggesting that nonallergic inflammation is a relatively poor inducer of this phenotype change in mice. When a "subclinical" infection of the lungs with the human A2 strain of respiratory syncytial virus was superimposed on the model of atopic asthma, recruitment of monocytes and lymphocytes to the airways was enhanced and a discharge of goblet cell mucin contents was observed. This may partly explain the respiratory difficulty that typifies virally induced exacerbations of asthma in humans. Daily systemic treatment of sensitized mice with dexamethasone during the period of allergen challenge produced a dose-related suppression of developing GCH, while similar treatment during the period following the establishment of extensive hyperplasia induced an accelerated resolution toward a normal epithelial phenotype. These results confirm and extend the relevance of this model as a representation of the human disease.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
B. A. Stout, K. Melendez, J. Seagrave, M. J. Holtzman, B. Wilson, J. Xiang, and Y. Tesfaigzi
STAT1 Activation Causes Translocation of Bax to the Endoplasmic Reticulum during the Resolution of Airway Mucous Cell Hyperplasia by IFN-{gamma}
J. Immunol., June 15, 2007; 178(12): 8107 - 8116.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. R. Locke, S. G. Royce, J. S. Wainewright, C. S. Samuel, and M. L. Tang
Comparison of Airway Remodeling in Acute, Subacute, and Chronic Models of Allergic Airways Disease
Am. J. Respir. Cell Mol. Biol., May 1, 2007; 36(5): 625 - 632.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. J. Long, J. P. Sypek, R. Askew, S. C. Fish, L. E. Mason, C. M. M. Williams, and S. J. Goldman
Gob-5 Contributes to Goblet Cell Hyperplasia and Modulates Pulmonary Tissue Inflammation
Am. J. Respir. Cell Mol. Biol., September 1, 2006; 35(3): 357 - 365.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Y. Tesfaigzi
Roles of Apoptosis in Airway Epithelia
Am. J. Respir. Cell Mol. Biol., May 1, 2006; 34(5): 537 - 547.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. R. Henderson Jr., G. K. S. Chiang, Y.-t. Tien, and E. Y. Chi
Reversal of Allergen-induced Airway Remodeling by CysLT1 Receptor Blockade
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 718 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Hashimoto, B. S. Graham, S. B. Ho, K. B. Adler, R. D. Collins, S. J. Olson, W. Zhou, T. Suzutani, P. W. Jones, K. Goleniewska, et al.
Respiratory Syncytial Virus in Allergic Lung Inflammation Increases Muc5ac and Gob-5
Am. J. Respir. Crit. Care Med., August 1, 2004; 170(3): 306 - 312.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
I. Hussain, V. V. Jain, P. O'Shaughnessy, T. R. Businga, and J. Kline
Effect of Nitrogen Dioxide Exposure on Allergic Asthma in a Murine Model
Chest, July 1, 2004; 126(1): 198 - 204.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Bozinovski, J. Jones, S.-J. Beavitt, A. D. Cook, J. A. Hamilton, and G. P. Anderson
Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L877 - L885.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. K. Kumar, C. Herbert, P. S. Thomas, L. Wollin, R. Beume, M. Yang, D. C. Webb, and P. S. Foster
Inhibition of Inflammation and Remodeling by Roflumilast and Dexamethasone in Murine Chronic Asthma
J. Pharmacol. Exp. Ther., October 1, 2003; 307(1): 349 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. R. Reader, J. S. Tepper, E. S. Schelegle, M. C. Aldrich, L. F. Putney, J. W. Pfeiffer, and D. M. Hyde
Pathogenesis of Mucous Cell Metaplasia in a Murine Asthma Model
Am. J. Pathol., June 1, 2003; 162(6): 2069 - 2078.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
P. D. Vermeer, R. Harson, L. A. Einwalter, T. Moninger, and J. Zabner
Interleukin-9 Induces Goblet Cell Hyperplasia during Repair of Human Airway Epithelia
Am. J. Respir. Cell Mol. Biol., March 1, 2003; 28(3): 286 - 295.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Tesfaigzi, M. J. Fischer, M. Daheshia, F. H. Y. Green, G. T. De Sanctis, and J. A. Wilder
Bax is Crucial for IFN-{gamma}-Induced Resolution of Allergen- Induced Mucus Cell Metaplasia
J. Immunol., November 15, 2002; 169(10): 5919 - 5925.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Bozinovski, J. E. Jones, R. Vlahos, J. A. Hamilton, and G. P. Anderson
Granulocyte/Macrophage-Colony-stimulating Factor (GM-CSF) Regulates Lung Innate Immunity to Lipopolysaccharide through Akt/Erk Activation of NFkappa B and AP-1 in Vivo
J. Biol. Chem., November 1, 2002; 277(45): 42808 - 42814.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
N.J. Vanacker, E. Palmans, R.A. Pauwels, and J.C. Kips
Dose-related effect of inhaled fluticasone on allergen-induced airway changes in rats
Eur. Respir. J., October 1, 2002; 20(4): 873 - 879.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. M. Evans, D. I. Blyth, T. Wong, S. Sanjar, and M. R. West
Decreased Distribution of Lung Epithelial Junction Proteins after Intratracheal Antigen or Lipopolysaccharide Challenge: Correlation with Neutrophil Influx and Levels of BALF sE-Cadherin
Am. J. Respir. Cell Mol. Biol., October 1, 2002; 27(4): 446 - 454.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Jones, J.M. Qui, E. Bataki, H. Elphick, S. Ritson, G.S. Evans, and M.L. Everard
Neutrophil survival is prolonged in the airways of healthy infants and infants with RSV bronchiolitis
Eur. Respir. J., September 1, 2002; 20(3): 651 - 657.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. J. Toward and K. J. Broadley
Goblet Cell Hyperplasia, Airway Function, and Leukocyte Infiltration after Chronic Lipopolysaccharide Exposure in Conscious Guinea Pigs: Effects of Rolipram and Dexamethasone
J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 814 - 821.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. O-Quan Shi, M. J. Fischer, G. T. De Sanctis, M. R. Schuyler, and Y. Tesfaigzi
IFN-{gamma}, But Not Fas, Mediates Reduction of Allergen-Induced Mucous Cell Metaplasia by Inducing Apoptosis
J. Immunol., May 1, 2002; 168(9): 4764 - 4771.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Nakanishi, S. Morita, H. Iwashita, Y. Sagiya, Y. Ashida, H. Shirafuji, Y. Fujisawa, O. Nishimura, and M. Fujino
Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma
PNAS, April 5, 2001; (2001) 81510898.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. J. VANACKER, E. PALMANS, J. C. KIPS, and R. A. PAUWELS
Fluticasone Inhibits But Does Not Reverse Allergen-Induced Structural Airway Changes
Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): 674 - 679.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Komori, H. Inoue, K. Matsumoto, H. Koto, S. Fukuyama, H. Aizawa, and N. Hara
PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways
Am J Physiol Lung Cell Mol Physiol, March 1, 2001; 280(3): L436 - L441.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. Yanagihara, M. Seki, and P.-W. Cheng
Lipopolysaccharide Induces Mucus Cell Metaplasia in Mouse Lung
Am. J. Respir. Cell Mol. Biol., January 1, 2001; 24(1): 66 - 73.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. KANEHIRO, T. IKEMURA, M. J. MÄKELÄ, M. LAHN, A. JOETHAM, A. DAKHAMA, and E. W. GELFAND
Inhibition of Phosphodiesterase 4 Attenuates Airway Hyperresponsiveness and Airway Inflammation in a Model of Secondary Allergen Challenge
Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 173 - 184.
[Abstract] [Full Text]

Home page
 ThoraxHome page
A Kamachi, M Munakata, Y Nasuhara, M Nishimura, Y Ohtsuka, M Amishima, T Takahashi, Y Homma, and Y Kawakami
Enhancement of goblet cell hyperplasia and airway hyperresponsiveness by salbutamol in a rat model of atopic asthma
Thorax, January 1, 2001; 56(1): 19 - 24.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. KANEHIRO, K. TAKEDA, A. JOETHAM, A. TOMKINSON, T. IKEMURA, C. G. IRVIN, and E. W. GELFAND
Timing of Administration of Anti-VLA-4 Differentiates Airway Hyperresponsiveness in the Central and Peripheral Airways in Mice
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 1132 - 1139.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. I. Blyth, T. F. Wharton, M. S. Pedrick, T. J. Savage, and S. Sanjar
Airway Subepithelial Fibrosis in a Murine Model of Atopic Asthma . Suppression by Dexamethasone or Anti-Interleukin-5 Antibody
Am. J. Respir. Cell Mol. Biol., August 1, 2000; 23(2): 241 - 246.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. SHIMIZU, H. HIRANO, Y. MAJIMA, and Y. SAKAKURA
A Mechanism of Antigen-induced Mucus Production in Nasal Epithelium of Sensitized Rats . A Comparison with Lipopolysaccharide-induced Mucus Production
Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1648 - 1654.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. P. ANDERSON
Interactions between Corticosteroids and beta -Adrenergic Agonists in Asthma Disease Induction, Progression, and Exacerbation
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): S188 - 196.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. Braun, M. Lommatzsch, A. Mannsfeldt, U. Neuhaus-Steinmetz, A. Fischer, N. Schnoy, G. R. Lewin, and H. Renz
Cellular Sources of Enhanced Brain-Derived Neurotrophic Factor Production in a Mouse Model of Allergic Inflammation
Am. J. Respir. Cell Mol. Biol., October 1, 1999; 21(4): 537 - 546.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Nakanishi, S. Morita, H. Iwashita, Y. Sagiya, Y. Ashida, H. Shirafuji, Y. Fujisawa, O. Nishimura, and M. Fujino
Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma
PNAS, April 24, 2001; 98(9): 5175 - 5180.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 1998 American Thoracic Society.