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Am. J. Respir. Cell Mol. Biol., Volume 19, Number 2, August, 1998 245-249

The Pulmonary Hypertensive Fawn-hooded Rat Has a Normal Serotonin Transporter Coding Sequence

Ana-Maria Gonzalez, Adrian P. L. Smith, Celia J. Emery, and Timothy W. Higenbottam

Respiratory Medicine, Division of Clinical Science, University of Sheffield Medical School, Sheffield, United Kingdom

The coding sequence of the serotonin transporter gene was compared in two strains of rat---the Wistar and the fawn-hooded rat (FHR). The FHR has an inherited platelet storage-pool deficiency and a widespread impairment of serotonin storage. It is also susceptible to systemic and pulmonary hypertension. The FHR provides a model to study the genetics in human systemic and pulmonary hypertension. We measured platelet function in these two strains by measuring incorporation of radiolabeled serotonin into a platelet suspension and found significant differences in serotonin uptake and release. The coding sequence for the serotonin transporter in the FHR has yet to be reported. No differences were found in the predicted amino acid sequence between these two strains of rat, either in the platelet or the lung samples or when compared with the published sequence of the brown rat. We conclude that differences in the primary structure of the serotonin transporter gene do not account for the altered serotonin storage in the FHR strain.




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Copyright © 1998 American Thoracic Society.