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Am. J. Respir. Cell Mol. Biol., Volume 19, Number 4, October, 1998 700-708

Surfactant Protein-A-Deficient Mice Are Susceptible to Pseudomonas aeruginosa Infection

Ann Marie LeVine, Kim E. Kurak, Michael D. Bruno, James M. Stark, Jeffrey A. Whitsett, and Thomas R. Korfhagen

Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio

To determine the role of surfactant protein-A (SP-A) in host defense, the murine SP-A locus was targeted by homologous recombination to produce mice lacking SP-A. SP-A-/- and wild-type mice were infected with mucoid Pseudomonas aeruginosa by intratracheal instillation. Pulmonary bacterial loads were greater in SP-A-/- than in wild-type mice, with increased numbers of mucoid P. aeruginosa in lung homogenates at 6 and 24 h after infection. Pulmonary infiltration with polymorphonuclear leukocytes (PMN) was similar in both groups; however, an earlier influx of PMN into the lung occurred in the SP-A-/- mice. The number of bacteria phagocytosed by alveolar macrophages was decreased in the SP-A-/- mice at 1 h after infection. Superoxide-radical generation by PMN was similar for the SP-A-/- and wild-type mice, but nitrite levels were increased in SP-A-/- mice. Concentrations of tumor necrosis factor-alpha , interleukin-6, and macrophage inflammatory protein-2 (proinflammatory cytokines) were greater in bronchoalveolar lavage fluid at 2 h after infection in SP-A-/- mice. SP-A plays an important role in the pathogenesis of mucoid P. aeruginosa infection in the lung in vivo by enhancing macrophage phagocytosis and clearance of bacteria, and by modifying the inflammatory response.




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[Abstract] [Full Text] [PDF]

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Glycobiology, August 1, 2004; 14(8): 693 - 700.
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kudo, H. Sano#, H. Takahashi, K. Kuronuma, S.-i. Yokota, N. Fujii, K.-i. Shimada, I. Yano, Y. Kumazawa, D. R. Voelker, et al.
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J. Immunol., June 15, 2004; 172(12): 7592 - 7602.
[Abstract] [Full Text] [PDF]

Home page
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J. Lipid Res., June 1, 2004; 45(6): 1061 - 1068.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Kuronuma, H. Sano, K. Kato, K. Kudo, N. Hyakushima, S.-i. Yokota, H. Takahashi, N. Fujii, H. Suzuki, T. Kodama, et al.
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[Abstract] [Full Text] [PDF]

Home page
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Infect. Immun., May 1, 2004; 72(5): 2899 - 2906.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. A. Fulton, S. M. Reba, R. K. Pai, M. Pennini, M. Torres, C. V. Harding, and W. H. Boom
Inhibition of Major Histocompatibility Complex II Expression and Antigen Processing in Murine Alveolar Macrophages by Mycobacterium bovis BCG and the 19-Kilodalton Mycobacterial Lipoprotein
Infect. Immun., April 1, 2004; 72(4): 2101 - 2110.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. M. Hickman-Davis, J. Gibbs-Erwin, J. R. Lindsey, and S. Matalon
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Am. J. Respir. Cell Mol. Biol., March 1, 2004; 30(3): 319 - 325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. F. Alcorn and J. R. Wright
Surfactant protein A inhibits alveolar macrophage cytokine production by CD14-independent pathway
Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L129 - L136.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. P. Lopez, E. Clark, and V. L. Shepherd
Surfactant protein A enhances Mycobacterium avium ingestion but not killing by rat macrophages
J. Leukoc. Biol., October 1, 2003; 74(4): 523 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
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Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): 685 - 691.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-Z. Wang, C. L. Rosenberger, Y.-X. Bao, J. M. Stark, and K. S. Harrod
Clara Cell Secretory Protein Modulates Lung Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection
J. Immunol., July 15, 2003; 171(2): 1051 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
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[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. J. Borron, E. A. Mostaghel, C. Doyle, E. S. Walsh, M. G. McHeyzer-Williams, and J. R. Wright
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Home page
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M. Griese, M. Neumann, T. von Bredow, R. Schmidt, and F. Ratjen
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Eur. Respir. J., November 1, 2002; 20(5): 1284 - 1291.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
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Surfactant protein A enhances the phagocytosis of C1q-coated particles by alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L1011 - L1022.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. A. Beharka, C. D. Gaynor, B. K. Kang, D. R. Voelker, F. X. McCormack, and L. S. Schlesinger
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Home page
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Home page
 Am. J. Respir. Cell Mol. Bio.Home page
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Am. J. Respir. Cell Mol. Biol., September 1, 2002; 27(3): 353 - 360.
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Home page
 J. Biol. Chem.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Surfactant protein A regulates surfactant phospholipid clearance after LPS-induced injury in vivo
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[Abstract] [Full Text] [PDF]

Home page
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Am. J. Respir. Crit. Care Med., June 1, 2002; 165(11): 1546 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
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Lung Infections Associated with Cystic Fibrosis
Clin. Microbiol. Rev., April 1, 2002; 15(2): 194 - 222.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
R. J Boyton and P. J Openshaw
Pulmonary defences to acute respiratory infection
Br. Med. Bull., March 1, 2002; 61(1): 1 - 12.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
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Am. J. Respir. Cell Mol. Biol., March 1, 2002; 26(3): 257 - 260.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L573 - L584.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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