help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuwano, K.
Right arrow Articles by Hara, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuwano, K.
Right arrow Articles by Hara, N.

Am. J. Respir. Cell Mol. Biol., Volume 20, Number 1, January, 1999 53-60

The Involvement of Fas-Fas Ligand Pathway in Fibrosing Lung Diseases

Kazuyoshi Kuwano, Hiroyuki Miyazaki, Naoki Hagimoto, Masayuki Kawasaki, Masaki Fujita, Ritsuko Kunitake, Yumi Kaneko, and Nobuyuki Hara

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Pulmonary fibrosis begins with alveolitis, which progresses to destruction of lung tissue and excess collagen deposition. This process could be the result of DNA damage and a form of apoptosis. Therefore, we hypothesized that Fas ligand (FasL), which induces apoptosis in cells expressing Fas antigen (Fas), is associated with pulmonary fibrosis. We examined frozen lung tissues from seven patients with idiopathic pulmonary fibrosis (IPF), and bronchoalveolar lavage fluid (BALF) cells from 19 patients with IPF and from 17 patients with interstitial pneumonia associated with collagen vascular diseases (CVD-IP). We used five frozen lungs with normal lung parenchyma and BALF cells from 10 patients with solitary pulmonary nodule as controls. Reverse transcription-polymerase chain reaction (RT-PCR) showed that FasL messenger RNA (mRNA) was expressed in BALF cells from all patients with IPF and from 15 of 16 patients with CVD-IP. FasL mRNA was not detected in BALF cells except in one of 10 controls. RT in situ PCR detected FasL mRNA in inflammatory cells in BALF from patients with IPF. Immunohistochemistry detected FasL protein in infiltrating lymphocytes and granulocytes in all of seven frozen lung tissues of IPF, but in none of five control lung tissues. Additionally, the expression of Fas appeared to be upregulated in bronchiolar and alveolar epithelial cells in IPF compared with normal lung parenchyma by immunohistochemistry. We conclude that Fas and FasL were upregulated in fibrosing lung diseases and may associate with DNA damage or apoptosis of bronchiolar and alveolar epithelial cells in this disorder.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. D. Lopez, S. Avasarala, S. Grewal, A. K. Murali, and L. London
Differential Role of the Fas/Fas Ligand Apoptotic Pathway in Inflammation and Lung Fibrosis Associated with Reovirus 1/L-Induced Bronchiolitis Obliterans Organizing Pneumonia and Acute Respiratory Distress Syndrome
J. Immunol., December 15, 2009; 183(12): 8244 - 8257.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. C. Caldwell, Y. Chen, H. S. Goetzmann, Y. Hao, M. T. Borchers, D. J. Hassett, L. R. Young, D. Mavrodi, L. Thomashow, and G. W. Lau
Pseudomonas aeruginosa Exotoxin Pyocyanin Causes Cystic Fibrosis Airway Pathogenesis
Am. J. Pathol., December 1, 2009; 175(6): 2473 - 2488.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
P. Y. Cohen, R. Breuer, and S. B. Wallach-Dayan
Thy1 Up-Regulates FasL Expression in Lung Myofibroblasts via Src Family Kinases
Am. J. Respir. Cell Mol. Biol., February 1, 2009; 40(2): 231 - 238.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Drakopanagiotakis, A. Xifteri, V. Polychronopoulos, and D. Bouros
Apoptosis in lung injury and fibrosis
Eur. Respir. J., December 1, 2008; 32(6): 1631 - 1638.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Yamasaki, H.-R. Kang, R. J. Homer, S. P. Chapoval, S. J. Cho, B. J. Lee, J. A. Elias, and C. G. Lee
P21 Regulates TGF-{beta}1-Induced Pulmonary Responses via a TNF-{alpha}-Signaling Pathway
Am. J. Respir. Cell Mol. Biol., March 1, 2008; 38(3): 346 - 353.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
L. R. Young, R. Pasula, P. M. Gulleman, G. H. Deutsch, and F. X. McCormack
Susceptibility of Hermansky-Pudlak Mice to Bleomycin-Induced Type II Cell Apoptosis and Fibrosis
Am. J. Respir. Cell Mol. Biol., July 1, 2007; 37(1): 67 - 74.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. Golan-Gerstl, S. B. Wallach-Dayan, G. Amir, and R. Breuer
Epithelial Cell Apoptosis by Fas Ligand-Positive Myofibroblasts in Lung Fibrosis
Am. J. Respir. Cell Mol. Biol., March 1, 2007; 36(3): 270 - 275.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. B. Wallach-Dayan, G. Izbicki, P. Y. Cohen, R. Gerstl-Golan, A. Fine, and R. Breuer
Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway
Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L790 - L796.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
W. Matsuyama, M. Watanabe, Y. Shirahama, H. Mitsuyama, I. Higashimoto, M. Osame, and K. Arimura
Discoidin Domain Receptor 1 Contributes to the Survival of Lung Fibroblast in Idiopathic Pulmonary Fibrosis
Am. J. Pathol., March 1, 2006; 168(3): 866 - 877.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
V. J. Thannickal and J. C. Horowitz
Evolving concepts of apoptosis in idiopathic pulmonary fibrosis.
Proceedings of the ATS, January 1, 2006; 3(4): 350 - 356.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. A. Beamer and A. Holian
Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis following silica exposure
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L186 - L195.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. A. Neff, R.-F. Guo, S. B. Neff, J. V. Sarma, C. L. Speyer, H. Gao, K. D. Bernacki, M. Huber-Lang, S. McGuire, L. M. Hoesel, et al.
Relationship of Acute Lung Inflammatory Injury to Fas/FasL System
Am. J. Pathol., March 1, 2005; 166(3): 685 - 694.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. Wang, L. Bowman, Y. Lu, Y. Rojanasakul, R. R. Mercer, V. Castranova, and M. Ding
Essential role of p53 in silica-induced apoptosis
Am J Physiol Lung Cell Mol Physiol, March 1, 2005; 288(3): L488 - L496.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Plataki, A. V. Koutsopoulos, K. Darivianaki, G. Delides, N. M. Siafakas, and D. Bouros
Expression of Apoptotic and Antiapoptotic Markers in Epithelial Cells in Idiopathic Pulmonary Fibrosis
Chest, January 1, 2005; 127(1): 266 - 274.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. S. Bogatkevich, E. Gustilo, J. C. Oates, C. Feghali-Bostwick, R. A. Harley, R. M. Silver, and A. Ludwicka-Bradley
Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts
Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L190 - L201.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
H Miyazaki, K Kuwano, K Yoshida, T Maeyama, M Yoshimi, M Fujita, N Hagimoto, R Yoshida, and Y Nakanishi
The perforin mediated apoptotic pathway in lung injury and fibrosis
J. Clin. Pathol., December 1, 2004; 57(12): 1292 - 1298.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. G. Lee, S. J. Cho, M. J. Kang, S. P. Chapoval, P. J. Lee, P. W. Noble, T. Yehualaeshet, B. Lu, R. A. Flavell, J. Milbrandt, et al.
Early Growth Response Gene 1-mediated Apoptosis Is Essential for Transforming Growth Factor {beta}1-induced Pulmonary Fibrosis
J. Exp. Med., August 2, 2004; 200(3): 377 - 389.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. E. Kagan, G. G. Borisenko, B. F. Serinkan, Y. Y. Tyurina, V. A. Tyurin, J. Jiang, S. X. Liu, A. A. Shvedova, J. P. Fabisiak, W. Uthaisang, et al.
Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine
Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285(1): L1 - L17.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. Kuwano, N. Nakashima, I. Inoshima, N. Hagimoto, M. Fujita, M. Yoshimi, T. Maeyama, N. Hamada, K. Watanabe, and N. Hara
Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias
Eur. Respir. J., February 1, 2003; 21(2): 232 - 240.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Fujita, M. Maruyama, J. Araya, K. Sassa, Y. Kawagishi, R. Hayashi, S. Matsui, T. Kashii, N. Yamashita, E. Sugiyama, et al.
Hydrogen Peroxide Induces Upregulation of Fas in Human Airway Epithelial Cells via the Activation of PARP-p53 Pathway
Am. J. Respir. Cell Mol. Biol., November 1, 2002; 27(5): 542 - 552.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. H. Albertine, M. F. Soulier, Z. Wang, A. Ishizaka, S. Hashimoto, G. A. Zimmerman, M. A. Matthay, and L. B. Ware
Fas and Fas Ligand Are Up-Regulated in Pulmonary Edema Fluid and Lung Tissue of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome
Am. J. Pathol., November 1, 2002; 161(5): 1783 - 1796.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Tanaka, M. Yoshimi, T. Maeyama, N. Hagimoto, K. Kuwano, and N. Hara
Resistance to Fas-mediated apoptosis in human lung fibroblast
Eur. Respir. J., August 1, 2002; 20(2): 359 - 368.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Hagimoto, K. Kuwano, I. Inoshima, M. Yoshimi, N. Nakamura, M. Fujita, T. Maeyama, and N. Hara
TGF-{beta}1 as an Enhancer of Fas-Mediated Apoptosis of Lung Epithelial Cells
J. Immunol., June 15, 2002; 168(12): 6470 - 6478.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. R. Coulter, A. Doseff, P. Sweeney, Y. Wang, C. B. Marsh, M. D. Wewers, and D. L. Knoell
Opposing Effect by Cytokines on Fas-Mediated Apoptosis in A549 Lung Epithelial Cells
Am. J. Respir. Cell Mol. Biol., January 1, 2002; 26(1): 58 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. Matute-Bello, C. W. Frevert, W. C. Liles, M. Nakamura, J. T. Ruzinski, K. Ballman, V. A. Wong, C. Vathanaprida, and T. R. Martin
Fas/Fas Ligand System Mediates Epithelial Injury, but Not Pulmonary Host Defenses, in Response to Inhaled Bacteria
Infect. Immun., September 1, 2001; 69(9): 5768 - 5776.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Matute-Bello, W. C. Liles, C. W. Frevert, M. Nakamura, K. Ballman, C. Vathanaprida, P. A. Kiener, and T. R. Martin
Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits
Am J Physiol Lung Cell Mol Physiol, August 1, 2001; 281(2): L328 - L335.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. De Flora, A. Izzotti, F. D'Agostini, and R. M. Balansky
Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
Carcinogenesis, July 1, 2001; 22(7): 999 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Nemery, A. Bast, J. Behr, P.J.A. Borm, S.J. Bourke, Ph. Camus, P. De Vuyst, H.M. Jansen, V.L. Kinnula, D. Lison, et al.
Interstitial lung disease induced by exogenous agents: factors governing susceptibility
Eur. Respir. J., July 1, 2001; 18(32_suppl): 30S - 42s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Maeyama, K. Kuwano, M. Kawasaki, R. Kunitake, N. Hagimoto, and N. Hara
Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12
Am J Physiol Lung Cell Mol Physiol, June 1, 2001; 280(6): L1128 - L1137.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
F. D'Agostini, R. M. Balansky, A. Izzotti, R. A. Lubet, G. J. Kelloff, and S. De Flora
Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats
Carcinogenesis, March 1, 2001; 22(3): 375 - 380.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. KITAMURA, S. HASHIMOTO, N. MIZUTA, A. KOBAYASHI, K. KOOGUCHI, I. FUJIWARA, and H. NAKAJIMA
Fas/FasL-dependent Apoptosis of Alveolar Cells after Lipopolysaccharide-induced Lung Injury in Mice
Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): 762 - 769.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Maeyama, K. Kuwano, M. Kawasaki, R. Kunitake, N. Hagimoto, T. Matsuba, M. Yoshimi, I. Inoshima, K. Yoshida, and N. Hara
Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis
Eur. Respir. J., February 1, 2001; 17(2): 180 - 189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. L. Serrao, J. D. Fortenberry, M. L. Owens, F. L. Harris, and L. A. S. Brown
Neutrophils induce apoptosis of lung epithelial cells via release of soluble Fas ligand
Am J Physiol Lung Cell Mol Physiol, February 1, 2001; 280(2): L298 - L305.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
J V Barbas-Filho, M A Ferreira, A Sesso, R A Kairalla, C R R Carvalho, and V L Capelozzi
Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP)
J. Clin. Pathol., February 1, 2001; 54(2): 132 - 138.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Kasper, C. Roehlecke, M. Witt, H. Fehrenbach, A. Hofer, T. Miyata, C. Weigert, R. H. W. Funk, and E. D. Schleicher
Induction of Apoptosis by Glyoxal in Human Embryonic Lung Epithelial Cell Line L132
Am. J. Respir. Cell Mol. Biol., October 1, 2000; 23(4): 485 - 491.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Selman, V. Ruiz, S. Cabrera, L. Segura, R. Ramirez, R. Barrios, and A. Pardo
TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?
Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L562 - L574.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. Kuwano, M. Kawasaki, T. Maeyama, N. Hagimoto, N. Nakamura, K. Shirakawa, and N. Hara
Soluble Form of Fas and Fas Ligand in BAL Fluid From Patients With Pulmonary Fibrosis and Bronchiolitis Obliterans Organizing Pneumonia
Chest, August 1, 2000; 118(2): 451 - 458.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. AOSHIBA, S. YASUI, J. TAMAOKI, and A. NAGAI
The Fas/Fas-Ligand System Is Not Required for Bleomycin-induced Pulmonary Fibrosis in Mice
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 695 - 700.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Behnia, K. A. Robertson, and W. J. Martin II
Lung Infections : Role of Apoptosis in Host Defense and Pathogenesis of Disease
Chest, June 1, 2000; 117(6): 1771 - 1777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. Kuwano and N. Hara
Signal Transduction Pathways of Apoptosis and Inflammation Induced by the Tumor Necrosis Factor Receptor Family
Am. J. Respir. Cell Mol. Biol., February 1, 2000; 22(2): 147 - 149.
[Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. Hagimoto, K. Kuwano, M. Kawasaki, M. Yoshimi, Y. Kaneko, R. Kunitake, T. Maeyama, T. Tanaka, and N. Hara
Induction of Interleukin-8 Secretion and Apoptosis in Bronchiolar Epithelial Cells by Fas Ligation
Am. J. Respir. Cell Mol. Biol., September 1, 1999; 21(3): 436 - 445.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 1999 American Thoracic Society. 		  Portfolio of grants