help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Déry, R. E.
Right arrow Articles by Bissonnette, E. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Déry, R. E.
Right arrow Articles by Bissonnette, E. Y.

Am. J. Respir. Cell Mol. Biol., Volume 20, Number 3, March, 1999 407-412

IFN-gamma Potentiates the Release of TNF-alpha and MIP-1alpha by Alveolar Macrophages during Allergic Reactions

René E. Déry and Elyse Y. Bissonnette

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

Viral infections play an important role in the exacerbation of asthma. The production of interferons (IFNs) is well known to limit viral spread, but IFN-gamma can also prime alveolar macrophages to release more inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha ) and macrophage inflammatory protein-1alpha (MIP-1alpha ). Given the importance of these cytokines, we have investigated the effect of IFN-gamma on their release by alveolar macrophages during stimulation by immunoglobulin (Ig)E/anti-IgE. Alveolar macrophages from normal or Nippostrongylus brasiliensis-infected rats, the latter having increased numbers of low-affinity receptors for IgE (Fcvarepsilon RII) on their alveolar macrophages, were treated with IgE for 2 h and stimulated with anti-IgE for 18 h. The increase of TNF-alpha release (153 ± 48 pg/106 cells) by IgE/anti-IgE occurred only with alveolar macrophages from infected rats. The messenger RNA level for TNF-alpha in rat alveolar macrophages was also increased by stimulation with IgE/anti-IgE. Treatment with IFN-gamma prior to stimulation with IgE/anti-IgE showed a time- and concentration-dependent increase of TNF-alpha release. Interestingly, IgE/anti-IgE treatment did not stimulate the release of MIP-1alpha (15 ± 5 pg/106 cells), but IFN-gamma treatment alone and with IgE /anti-IgE significantly increased and potentiated MIP-1alpha release (98 ± 40 pg/106 cells) by alveolar macrophages, respectively. These results suggest that IFN-gamma produced at times such as during viral infections primes alveolar macrophages for enhanced release of inflammatory mediators during allergic reactions, thereby contributing to the inflammatory process.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. Arora, Y. Hernandez, J. R. Erb-Downward, R. A. McDonald, G. B. Toews, and G. B. Huffnagle
Role of IFN-{gamma} in Regulating T2 Immunity and the Development of Alternatively Activated Macrophages during Allergic Bronchopulmonary Mycosis
J. Immunol., May 15, 2005; 174(10): 6346 - 6356.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. Careau and E. Y. Bissonnette
Adoptive Transfer of Alveolar Macrophages Abrogates Bronchial Hyperresponsiveness
Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 22 - 27.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Pilette, Y. Ouadrhiri, J. Van Snick, J-C. Renauld, P. Staquet, J-P. Vaerman, and Y. Sibille
Oxidative burst in lipopolysaccharide-activated human alveolar macrophages is inhibited by interleukin-9
Eur. Respir. J., November 1, 2002; 20(5): 1198 - 1205.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Coulombe, B. Battistini, J. Stankova, P. Pouliot, and E. Y. Bissonnette
Endothelins regulate mediator production of rat tissue-cultured mucosal mast cells. Up-regulation of Th1 and inhibition of Th2 cytokines
J. Leukoc. Biol., May 1, 2002; 71(5): 829 - 836.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. Ménard and E. Y. Bissonnette
Priming of Alveolar Macrophages by Leukotriene D4 . Potentiation of Inflammation
Am. J. Respir. Cell Mol. Biol., October 1, 2000; 23(4): 572 - 577.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. MARGUET, T. P. DEAN, and J. O. WARNER
Soluble Intercellular Adhesion Molecule-1 (sICAM-1) and Interferon-Gamma in Bronchoalveolar Lavage Fluid from Children with Airway Diseases
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 1016 - 1022.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
J. Sirois, G. Menard, A. S. Moses, and E. Y. Bissonnette
Importance of Histamine in the Cytokine Network in the Lung Through H2 and H3 Receptors: Stimulation of IL-10 Production
J. Immunol., March 15, 2000; 164(6): 2964 - 2970.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. M. Hogaboam, K. Blease, B. Mehrad, M. L. Steinhauser, T. J. Standiford, S. L. Kunkel, and N. W. Lukacs
Chronic Airway Hyperreactivity, Goblet Cell Hyperplasia, and Peribronchial Fibrosis during Allergic Airway Disease Induced by Aspergillus fumigatus
Am. J. Pathol., February 1, 2000; 156(2): 723 - 732.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
D. R. Ehlenfield, K. Cameron, and R. C. Welliver
Eosinophilia at the Time of Respiratory Syncytial Virus Bronchiolitis Predicts Childhood Reactive Airway Disease
Pediatrics, January 1, 2000; 105(1): 79 - 83.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 1999 American Thoracic Society.