help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ortiz, L. A.
Right arrow Articles by Friedman, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ortiz, L. A.
Right arrow Articles by Friedman, M.

Am. J. Respir. Cell Mol. Biol., Volume 20, Number 4, April, 1999 825-833

Upregulation of the p75 But Not the p55 TNF-alpha Receptor mRNA after Silica and Bleomycin Exposure and Protection from Lung Injury in Double Receptor Knockout Mice

Luis A. Ortiz, Joseph Lasky, Giuseppe Lungarella, Eleonora Cavarra, Piero Martorana, William A. Banks, Jacques J. Peschon, Hans-Ludwig Schmidts, Arnold R. Brody, and Mitchell Friedman

Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Section of Endocrinology, and Department of Pathology, Tulane University Medical Center, New Orleans, Louisiana; Immunex Corporation, Seattle, Washington; Istituto di Patologia Generale, Universita di Siena, Siena, Italy; and Hoeschst Marion Roussel, Frankfurt, Germany

We have investigated a potential role for tumor necrosis factor (TNF)-alpha and its two receptors (p55 and p75) in lung injury. We used several varieties of mice exposed endotracheally to two fibrogenic agents, silica (0.2 g/kg) and bleomycin (4 U/kg). The lungs were analyzed at 14 and 28 d after exposure to bleomycin or silica, respectively, for TNF and TNF receptor (TNFR) messenger RNA (mRNA), hydroxyproline content, and histopathology. Silica induced increased (over saline-treated animals) expression of TNF mRNA in double TNFR knockout (Ko), C57BL/6, BALB/c, and 129/J mice. In contrast, bleomycin increased expression in all but BALB/c mice, which are resistant to the fibrogenic effects of this drug. mRNA expression of both receptors was constitutively expressed in all of the normal murine strains. Silica upregulated expression of the p75 receptor, but not the p55 receptor, in the C57BL/6, BALB/c, and 129/J mice. In comparison, bleomycin had little effect on either receptor in the bleomycin-resistant BALB/c mice. Hydroxyproline content of the lungs after treatment followed this same pattern, with significant increases caused by silica in the C57BL/6, BALB/c, and 129/J mice, whereas bleomycin caused no apparent increases in the BALB/c mice. Even though silica and bleomycin induced increases in TNF in the TNFR Ko mice, the mice were protected from the fibrogenic effects of these agents. This study supports the concept that TNF is a central mediator of interstitial pulmonary fibrosis.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
C. T. Migliaccio, M. C. Buford, F. Jessop, and A. Holian
The IL-4R{alpha} pathway in macrophages and its potential role in silica-induced pulmonary fibrosis
J. Leukoc. Biol., March 1, 2008; 83(3): 630 - 639.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. L. Fattman, F. Gambelli, G. Hoyle, B. R. Pitt, and L. A. Ortiz
Epithelial expression of TIMP-1 does not alter sensitivity to bleomycin-induced lung injury in C57BL/6 mice
Am J Physiol Lung Cell Mol Physiol, March 1, 2008; 294(3): L572 - L581.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H. Liu, H. Zhang, and H. J. Forman
Silica Induces Macrophage Cytokines through Phosphatidylcholine-Specific Phospholipase C with Hydrogen Peroxide
Am. J. Respir. Cell Mol. Biol., May 1, 2007; 36(5): 594 - 599.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. D. Reynolds, H. Shen, P. R. Reynolds, T. Betsuyaku, J. M. Pilewski, F. Gambelli, M. DeGuiseppe, L. A. Ortiz, and B. R. Stripp
Molecular and functional properties of lung SP cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L972 - L983.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. K. Frankel, B. M. Moats-Staats, C. D. Cool, M. W. Wynes, A. D. Stiles, and D. W. H. Riches
Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L805 - L812.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Cavarra, F. Carraro, S. Fineschi, A. Naldini, B. Bartalesi, A. Pucci, and G. Lungarella
Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1186 - L1192.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
V. Barbarin, M. Arras, P. Misson, M. Delos, B. McGarry, S. H. Phan, D. Lison, and F. Huaux
Characterization of the Effect of Interleukin-10 on Silica-Induced Lung Fibrosis in Mice
Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 78 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
W. Huang, G. Wang, D. S. Phelps, H. Al-Mondhiry, and J. Floros
Human SP-A genetic variants and bleomycin-induced cytokine production by THP-1 cells: effect of ozone-induced SP-A oxidation
Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L546 - L553.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Gambelli, P. Di, X. Niu, M. Friedman, T. Hammond, D. W. H. Riches, and L. A. Ortiz
Phosphorylation of Tumor Necrosis Factor Receptor 1 (p55) Protects Macrophages from Silica-induced Apoptosis
J. Biol. Chem., January 16, 2004; 279(3): 2020 - 2029.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Fujita, J. M. Shannon, O. Morikawa, J. Gauldie, N. Hara, and R. J. Mason
Overexpression of Tumor Necrosis Factor-{alpha} Diminishes Pulmonary Fibrosis Induced by Bleomycin or Transforming Growth Factor-{beta}
Am. J. Respir. Cell Mol. Biol., December 1, 2003; 29(6): 669 - 676.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Jakubzick, E. S. Choi, B. H. Joshi, M. P. Keane, S. L. Kunkel, R. K. Puri, and C. M. Hogaboam
Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells
J. Immunol., September 1, 2003; 171(5): 2684 - 2693.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. Ortiz, F. Gambelli, C. McBride, D. Gaupp, M. Baddoo, N. Kaminski, and D. G. Phinney
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
PNAS, July 8, 2003; 100(14): 8407 - 8411.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K.-i. Inoue, H. Takano, R. Yanagisawa, T. Yoshikawa, R. Vassallo, E. L. Matteson, and C. F. Thomas Jr.
Effects of Tumor Necrosis Factor-{alpha} Inhibitors on Lung Lesions With Rheumatoid Arthritis
Chest, July 1, 2003; 124(1): 413 - 414.
[Full Text] [PDF]

Home page
 Toxicol SciHome page
G. S. Pryhuber, H. L. Huyck, R. Baggs, G. Oberdorster, and J. N. Finkelstein
Induction of Chemokines by Low-Dose Intratracheal Silica Is Reduced in TNFR I (p55) Null Mice
Toxicol. Sci., March 1, 2003; 72(1): 150 - 157.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Kuroki, Y. Noguchi, M. Shimono, K. Tomono, T. Tashiro, Y. Obata, E. Nakayama, and S. Kohno
Repression of Bleomycin-Induced Pneumopathy by TNF
J. Immunol., January 1, 2003; 170(1): 567 - 574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. S. Warshamana, D. A. Pociask, P. Sime, D. A. Schwartz, and A. R. Brody
Susceptibility to Asbestos-Induced and Transforming Growth Factor-{beta}1-Induced Fibroproliferative Lung Disease in Two Strains of Mice
Am. J. Respir. Cell Mol. Biol., December 1, 2002; 27(6): 705 - 713.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. Gozal, L. A. Ortiz, X. Zou, M. E. Burow, J. A. Lasky, and M. Friedman
Silica-Induced Apoptosis in Murine Macrophage . Involvement of Tumor Necrosis Factor-alpha and Nuclear Factor-kappa B Activation
Am. J. Respir. Cell Mol. Biol., July 1, 2002; 27(1): 91 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
W. Huang, G. Wang, D. S. Phelps, H. Al-Mondhiry, and J. Floros
Combined SP-A-bleomycin effect on cytokines by THP-1 cells: impact of surfactant lipids on this effect
Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L94 - L102.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Matsuoka, T. Arai, M. Mori, S. Goya, H. Kida, H. Morishita, H. Fujiwara, I. Tachibana, T. Osaki, and S. Hayashi
A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L103 - L112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. Tanino, H. Makita, K. Miyamoto, T. Betsuyaku, Y. Ohtsuka, J. Nishihira, and M. Nishimura
Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice
Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L156 - L162.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. L. CORBETT, N. MOZZATO-CHAMAY, A. E. BUTTERWORTH, K. M. DE COCK, B. G. WILLIAMS, G. J. CHURCHYARD, and D. J. CONWAY
Polymorphisms in the Tumor Necrosis Factor-alpha Gene Promoter May Predispose to Severe Silicosis in Black South African Miners
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 690 - 693.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. D. SRIVASTAVA, W. N. ROM, J. JAGIRDAR, T.-A. YIE, T. GORDON, and K.-M. TCHOU-WONG
Crucial Role of Interleukin-1beta and Nitric Oxide Synthase in Silica-induced Inflammation and Apoptosis in Mice
Am. J. Respir. Crit. Care Med., February 15, 2002; 165(4): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. B. Moore, R. Paine III, P. J. Christensen, T. A. Moore, S. Sitterding, R. Ngan, C. A. Wilke, W. A. Kuziel, and G. B. Toews
Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling
J. Immunol., October 15, 2001; 167(8): 4368 - 4377.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Y. K. Zhu, X. D. Liu, M. C. Skold, T. Umino, H. Wang, D. J. Romberger, J. R. Spurzem, T. Kohyama, F.-Q. Wen, and S. I. Rennard
Cytokine Inhibition of Fibroblast-Induced Gel Contraction Is Mediated by PGE2 and NO Acting Through Separate Parallel Pathways
Am. J. Respir. Cell Mol. Biol., August 1, 2001; 25(2): 245 - 253.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J.-Y. Liu, P. J. Sime, T. Wu, G. S. Warshamana, D. Pociask, S.-Y. Tsai, and A. R. Brody
Transforming Growth Factor-beta 1 Overexpression in Tumor Necrosis Factor-alpha Receptor Knockout Mice Induces Fibroproliferative Lung Disease
Am. J. Respir. Cell Mol. Biol., July 1, 2001; 25(1): 3 - 7.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.J.A. Borm and R.P.F. Schins
Genotype and phenotype in susceptibility to coal workers' pneumoconiosis. The use of cytokines in perspective
Eur. Respir. J., July 1, 2001; 18(32_suppl): 127S - 133s.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. A. Ortiz, J. A. Lasky, E. Gozal, A. R. Brody, A. Pardo, M. Selman, V. Ruiz, and M. Friedman
Tumor Necrosis Factor Receptor Deficiency Protects Mice From Silica-Induced Lung Fibrosis by Altering Lung Matrix Metalloproteinase-13/Tissue Inhibitor of Metalloproteinase-1 RNA Expression and Decreasing Activating Protein-1 Activation
Chest, July 1, 2001; 120(1_suppl): 2S - 3S.
[Full Text] [PDF]

Home page
 ChestHome page
A. R. Brody, G. S. Warshamana, Jing-Yao, and D. A. Pociask
Expression of Transforming Growth Factor-{beta} Induces Fibroproliferative Pulmonary Disease in Fibrosis-Resistant Mice
Chest, July 1, 2001; 120(2007): 48S - 49S.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. PANTELIDIS, G. C. FANNING, A. U. WELLS, K. I. WELSH, and R. M. DU BOIS
Analysis of Tumor Necrosis Factor-{alpha}, Lymphotoxin-{alpha}, Tumor Necrosis Factor Receptor II, and Interleukin-6 Polymorphisms in Patients with Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., May 1, 2001; 163(6): 1432 - 1436.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H.-Y. Cho, L.-Y. Zhang, and S. R. Kleeberger
Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-{alpha} receptors
Am J Physiol Lung Cell Mol Physiol, March 1, 2001; 280(3): L537 - L546.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. A. ORTIZ, J. LASKY, E. GOZAL, V. RUIZ, G. LUNGARELLA, E. CAVARRA, A. R. BRODY, M. FRIEDMAN, A. PARDO, and M. SELMAN
Tumor Necrosis Factor Receptor Deficiency Alters Matrix Metalloproteinase 13/Tissue Inhibitor of Metalloproteinase 1 Expression in Murine Silicosis
Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 244 - 252.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. C. Savani, Z. Zhou, E. Arguiri, S. Wang, D. Vu, C. C. Howe, and H. M. DeLisser
Bleomycin-induced pulmonary injury in mice deficient in SPARC
Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L743 - L750.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Tokuda, M. Itakura, N. Onai, H. Kimura, T. Kuriyama, and K. Matsushima
Pivotal Role of CCR1-Positive Leukocytes in Bleomycin- Induced Lung Fibrosis in Mice
J. Immunol., March 1, 2000; 164(5): 2745 - 2751.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. Kuwano and N. Hara
Signal Transduction Pathways of Apoptosis and Inflammation Induced by the Tumor Necrosis Factor Receptor Family
Am. J. Respir. Cell Mol. Biol., February 1, 2000; 22(2): 147 - 149.
[Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. A. Ortiz, J. A. Lasky, H. Safah, M. Reyes, A. Miller, G. Lungarella, and M. Friedman
Exacerbation of bleomycin-induced lung injury in mice by amifostine
Am J Physiol Lung Cell Mol Physiol, December 1, 1999; 277(6): L1239 - L1244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. A. Ortiz, H. C. Champion, J. A. Lasky, F. Gambelli, E. Gozal, G. W. Hoyle, M. B. Beasley, A. L. Hyman, M. Friedman, and P. J. Kadowitz
Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-kappa B and AP-1
Am J Physiol Lung Cell Mol Physiol, June 1, 2002; 282(6): L1209 - L1221.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 1999 American Thoracic Society.