help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by , M. K.T.
Right arrow Articles by Sly, P. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by , M. K.T.
Right arrow Articles by Sly, P. D.

Am. J. Respir. Cell Mol. Biol., Volume 22, Number 5, May, 2000 604-612

Modification of the Inflammatory Response to Allergen Challenge after Exposure to Bacterial Lipopolysaccharide

Meri K.Tuli c', Janet L. Wale, Patrick G. Holt, and Peter D. Sly

TVW Telethon Institute for Child Health Research; and University of Western Australia Department of Paediatrics, Perth, Australia

The potential role of respiratory infections in altering the development of atopy and asthma is complex. Infections have been suggested to be effective in preventing the induction of T-helper 2-polarized allergen-specific immunity in early life, but also to exacerbate asthma in older, sensitized individuals. The mechanism(s) underlying these effects are poorly defined. The aim of this work was to determine the influence of lipopolysaccharide (LPS) exposure on the development of sensitization to allergen and the response to allergen challenge in vivo. Piebald-Virol-Glaxo rats were exposed to a single aerosol of LPS 1 d before or 1, 2, 4, 6, 8, or 10 d after sensitization with ovalbumin (OVA). On Day 11 animals were exposed to 1% OVA and responses to allergen were measured 24 h later, monitoring inflammatory cell influx and microvascular leakage into bronchoalveolar lavage (BAL) fluid as well as pulmonary responses to methacholine using the forced oscillation technique. Histologic analysis was included to complement the BAL results. Single aerosol exposure to LPS 1 d before and up to 4 d after intraperitoneal injection of OVA protected against the development of OVA-specific immunoglobulin (Ig) E. LPS exposure 6, 8, or 10 d after sensitization further exacerbated the OVA-induced cellular influx, resulting in neutrophilia and increased Evans Blue dye leakage with no effect on serum IgE levels. In addition, LPS abolished the OVA-induced hyperresponsiveness in sensitized animals when given 18 h after OVA challenge. This study demonstrates that exposure to LPS can modify the development of allergic inflammation in vivo by two independent mechanisms. Exposure early in the sensitization process, up to Day 6 after exposure to allergen, prevented allergen sensitization. Exposure to LPS after allergen challenge in sensitized animals abolished the hyperresponsiveness and modified the inflammatory cell influx characteristic of late-phase response to allergen.




This article has been cited by other articles:


Home page
 Arch Pediatr Adolesc MedHome page
T. Dunder, T. Tapiainen, T. Pokka, and M. Uhari
Infections in Child Day Care Centers and Later Development of Asthma, Allergic Rhinitis, and Atopic Dermatitis: Prospective Follow-up Survey 12 Years After Controlled Randomized Hygiene Intervention
Arch Pediatr Adolesc Med, October 1, 2007; 161(10): 972 - 977.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
R. Yanagisawa, H. Takano, T. Ichinose, K. Mizushima, M. Nishikawa, I. Mori, K.-i. Inoue, K. Sadakane, and T. Yoshikawa
Gene Expression Analysis of Murine Lungs Following Pulmonary Exposure to Asian Sand Dust Particles
Experimental Biology and Medicine, September 1, 2007; 232(8): 1109 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. W. Kramer, S. N. Joshi, T. J. M. Moss, J. P. Newnham, R. Sindelar, A. H. Jobe, and S. G. Kallapur
Endotoxin-induced maturation of monocytes in preterm fetal sheep lung
Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L345 - L353.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. S. Noakes, J. Hale, R. Thomas, C. Lane, S. G. Devadason, and S. L. Prescott
Maternal smoking is associated with impaired neonatal toll-like-receptor-mediated immune responses
Eur. Respir. J., October 1, 2006; 28(4): 721 - 729.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. L. S. George, M. L. White, K. Kulhankova, A. Mahajan, P. S. Thorne, J. M. Snyder, and J. N. Kline
Early exposure to a nonhygienic environment alters pulmonary immunity and allergic responses
Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L512 - L522.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. W. Hollingsworth, G. S. Whitehead, K. L. Lin, H. Nakano, M. D. Gunn, D. A. Schwartz, and D. N. Cook
TLR4 Signaling Attenuates Ongoing Allergic Inflammation
J. Immunol., May 15, 2006; 176(10): 5856 - 5862.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. I. Nigo, M. Yamashita, K. Hirahara, R. Shinnakasu, M. Inami, M. Kimura, A. Hasegawa, Y. Kohno, and T. Nakayama
Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function
PNAS, February 14, 2006; 103(7): 2286 - 2291.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. S. Robbins, M. A. Pouladi, R. Fattouh, D. E. Dawe, N. Vujicic, C. D. Richards, M. Jordana, M. D. Inman, and M. R. Stampfli
Mainstream Cigarette Smoke Exposure Attenuates Airway Immune Inflammatory Responses to Surrogate and Common Environmental Allergens in Mice, Despite Evidence of Increased Systemic Sensitization
J. Immunol., September 1, 2005; 175(5): 2834 - 2842.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Choudhry, P. C. Avila, S. Nazario, N. Ung, J. Kho, J. R. Rodriguez-Santana, J. Casal, H.-J. Tsai, A. Torres, E. Ziv, et al.
CD14 Tobacco Gene-Environment Interaction Modifies Asthma Severity and Immunoglobulin E Levels in Latinos with Asthma
Am. J. Respir. Crit. Care Med., July 15, 2005; 172(2): 173 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. Velasco, M. Campo, O. J. Manrique, A. Bellou, H. He, R. S. S. Arestides, B. Schaub, D. L. Perkins, and P. W. Finn
Toll-Like Receptor 4 or 2 Agonists Decrease Allergic Inflammation
Am. J. Respir. Cell Mol. Biol., March 1, 2005; 32(3): 218 - 224.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
R. Yanagisawa, H. Takano, K.-I. Inoue, T. Ichinose, S.-i. Yoshida, K. Sadakane, K. Takeda, S. Yoshino, K. Yamaki, Y. Kumagai, et al.
Complementary DNA Microarray Analysis in Acute Lung Injury Induced by Lipopolysaccharide and Diesel Exhaust Particles
Experimental Biology and Medicine, November 1, 2004; 229(10): 1081 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H. Kuipers, C. Heirman, D. Hijdra, F. Muskens, M. Willart, S. van Meirvenne, K. Thielemans, H. C. Hoogsteden, and B. N. Lambrecht
Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization
J. Leukoc. Biol., November 1, 2004; 76(5): 1028 - 1038.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Matsushima, N. Yamada, H. Matsue, and S. Shimada
TLR3-, TLR7-, and TLR9-Mediated Production of Proinflammatory Cytokines and Chemokines from Murine Connective Tissue Type Skin-Derived Mast Cells but Not from Bone Marrow-Derived Mast Cells
J. Immunol., July 1, 2004; 173(1): 531 - 541.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. Hizawa, E. Yamaguchi, D. Takahashi, J. Nishihira, and M. Nishimura
Functional Polymorphisms in the Promoter Region of Macrophage Migration Inhibitory Factor and Atopy
Am. J. Respir. Crit. Care Med., May 1, 2004; 169(9): 1014 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Kabesch and R. P. Lauener
Why Old McDonald had a farm but no allergies: genes, environments, and the hygiene hypothesis
J. Leukoc. Biol., March 1, 2004; 75(3): 383 - 387.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. K. Lundy, A. A. Berlin, and N. W. Lukacs
Interleukin-12-Independent Down-Modulation of Cockroach Antigen-Induced Asthma in Mice by Intranasal Exposure to Bacterial Lipopolysaccharide
Am. J. Pathol., November 1, 2003; 163(5): 1961 - 1968.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
O. Michel
Role of lipopolysaccharide (LPS) in asthma and other pulmonary conditions
Innate Immunity, October 1, 2003; 9(5): 293 - 300.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
H. Kuipers, D. Hijdra, V. C. de Vries, H. Hammad, J.-B. Prins, A. J. Coyle, H. C. Hoogsteden, and B. N. Lambrecht
Lipopolysaccharide-Induced Suppression of Airway Th2 Responses Does Not Require IL-12 Production by Dendritic Cells
J. Immunol., October 1, 2003; 171(7): 3645 - 3654.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.C. Kips, G.P. Anderson, J.J. Fredberg, U. Herz, M.D. Inman, M. Jordana, D.M. Kemeny, J. Lotvall, R.A. Pauwels, C.G. Plopper, et al.
Murine models of asthma
Eur. Respir. J., August 1, 2003; 22(2): 374 - 382.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Rodriguez, A. C. Keller, E. L. Faquim-Mauro, M. S. de Macedo, F. Q. Cunha, J. Lefort, B. B. Vargaftig, and M. Russo
Bacterial Lipopolysaccharide Signaling Through Toll-Like Receptor 4 Suppresses Asthma-Like Responses Via Nitric Oxide Synthase 2 Activity
J. Immunol., July 15, 2003; 171(2): 1001 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 ANN OCCUP HYGHome page
J. DOUWES, P. THORNE, N. PEARCE, and D. HEEDERIK
Bioaerosol Health Effects and Exposure Assessment: Progress and Prospects
Ann. Hyg., April 1, 2003; 47(3): 187 - 200.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. C. Eisenbarth, D. A. Piggott, J. W. Huleatt, I. Visintin, C. A. Herrick, and K. Bottomly
Lipopolysaccharide-enhanced, Toll-like Receptor 4-dependent T Helper Cell Type 2 Responses to Inhaled Antigen
J. Exp. Med., December 16, 2002; 196(12): 1645 - 1651.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
J. Douwes and N. Pearce
Asthma and the westernization 'package'
Int. J. Epidemiol., December 1, 2002; 31(6): 1098 - 1102.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. A. Raby, W. T. Klimecki, C. Laprise, Y. Renaud, J. Faith, M. Lemire, C. Greenwood, K. M. Weiland, C. Lange, L. J. Palmer, et al.
Polymorphisms in Toll-Like Receptor 4 Are Not Associated with Asthma or Atopy-related Phenotypes
Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1449 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Masuda, Y. Yoshikai, K. Aiba, and T. Matsuguchi
Th2 Cytokine Production from Mast Cells Is Directly Induced by Lipopolysaccharide and Distinctly Regulated by c-Jun N-Terminal Kinase and p38 Pathways
J. Immunol., October 1, 2002; 169(7): 3801 - 3810.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
U. Gehring, W. Bischof, B. Fahlbusch, H.-E. Wichmann, and J. Heinrich
House Dust Endotoxin and Allergic Sensitization in Children
Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 939 - 944.
[Abstract] [Full Text]

Home page
 NEJMHome page
C. Braun-Fahrlander, J. Riedler, U. Herz, W. Eder, M. Waser, L. Grize, S. Maisch, D. Carr, F. Gerlach, A. Bufe, et al.
Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children
N. Engl. J. Med., September 19, 2002; 347(12): 869 - 877.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Heinrich, G. Bolte, B. Holscher, J. Douwes, I. Lehmann, B. Fahlbusch, W. Bischof, M. Weiss, M. Borte, and H-E. Wichmann
Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates
Eur. Respir. J., September 1, 2002; 20(3): 617 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
R. Rylander
Review: Endotoxin in the environment -- exposure and effects
Innate Immunity, August 1, 2002; 8(4): 241 - 252.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
K. Dabbagh, M. E. Dahl, P. Stepick-Biek, and D. B. Lewis
Toll-Like Receptor 4 Is Required for Optimal Development of Th2 Immune Responses: Role of Dendritic Cells
J. Immunol., May 1, 2002; 168(9): 4524 - 4530.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Renz and U. Herz
The bidirectional capacity of bacterial antigens to modulate allergy and asthma
Eur. Respir. J., January 1, 2002; 19(1): 158 - 171.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J Douwes, N Pearce, and D Heederik
Does environmental endotoxin exposure prevent asthma?
Thorax, January 1, 2002; 57(1): 86 - 90.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. M. Lilly and B. L. Daugherty
A Novel LPS-Inducible CCR3 Activator . Why So Many CCR3 Ligands?
Am. J. Respir. Cell Mol. Biol., December 1, 2001; 25(6): 673 - 675.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Kim, A. C. Merry, J. A. Nemzek, G. L. Bolgos, J. Siddiqui, and D. G. Remick
Eotaxin Represents the Principal Eosinophil Chemoattractant in a Novel Murine Asthma Model Induced by House Dust Containing Cockroach Allergens
J. Immunol., September 1, 2001; 167(5): 2808 - 2815.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Gruber, S. Lau, A. Dannemann, C. Sommerfeld, U. Wahn, and R. C. Aalberse
Down-Regulation of IgE and IgG4 Antibodies to Tetanus Toxoid and Diphtheria Toxoid by Covaccination with Cellular Bordetella pertussis Vaccine
J. Immunol., August 15, 2001; 167(4): 2411 - 2417.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. A. Knight, P. G. Holt, and P. D. Sly
Lipopolysaccharide Inhibits the Late-Phase Response to Allergen by Altering Nitric Oxide Synthase Activity and Interleukin-10
Am. J. Respir. Cell Mol. Biol., May 1, 2001; 24(5): 640 - 646.
[Abstract] [Full Text]

Home page
 Innate ImmunityHome page
D. Vercelli, M. Baldini, D. Stern, I. C. Lohman, M. Halonen, and F. Martinez
CD14: a bridge between innate immunity and adaptive IgE responses
Innate Immunity, February 1, 2001; 7(1): 45 - 48.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. A. Schwartz
Does Inhalation of Endotoxin Cause Asthma?
Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 305 - 306.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 2000 American Thoracic Society.