Am. J. Respir. Cell Mol. Biol.,
Volume 22, Number 6, June, 2000 714-721
 , and IL-1 , but Not IL-6, Induce
Human -Defensin-2 in Respiratory Epithelia
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, and interleukin (IL)-1
, but
not IL-6, dose-dependently induced hBD-2 messenger RNA in
cultured normal bronchial, tracheal, as well as normal and CF-derived nasal epithelial cells. Genomic analysis of hBD-2 revealed a promoter region containing several putative transcription factor binding sites, including nuclear factor (NF) 
B,
activator protein (AP)-1, AP-2, and NF-IL-6, known to be involved in the regulation of inflammatory responses. Thus, hBD-2 represents a major inducible antimicrobial factor released by airway epithelial cells either on contact with mucoid
PA or by endogenously produced primary cytokines. Therefore, it might be important in lung infections caused by mucoid PA, including those seen in patients with CF.
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