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Am. J. Respir. Cell Mol. Biol., Volume 25, Number 3, September, 2001 335-340

Interleukin-17 and Lung Host Defense against Klebsiella pneumoniae Infection

Peng Ye, Patrick B. Garvey, Ping Zhang, Steve Nelson, Greg Bagby, Warren R. Summer, Paul Schwarzenberger, Judd E. Shellito, and Jay K. Kolls

Gene Therapy Program, Section of Pulmonary and Critical Care, Louisiana State University Health Sciences Center, New Orleans, Louisiana

Bacterial pneumonia remains an important cause of morbidity and mortality worldwide, especially in immune-compromised patients. Cytokines and chemokines are critical molecules expressed in response to invading pathogens and are necessary for normal lung bacterial host defenses. Here we show that interleukin (IL)-17, a novel cytokine produced largely by CD4+ T cells, is produced in a compartmentalized fashion in the lung after challenge with Klebsiella pneumoniae. Moreover, overexpression of IL-17 in the pulmonary compartment using a recombinant adenovirus encoding murine IL-17 (AdIL-17) resulted in the local induction of tumor necrosis factor-alpha , IL-1beta , macrophage inflammatory protein-2, and granulocyte colony-stimulating factor (G-CSF); augmented polymorphonuclear leukocyte recruitment; and enhanced bacterial clearance and survival after challenge with K. pneumoniae. However, simultaneous treatment with AdIL-17 provided no survival benefit after intranasal K. pneumoniae challenge. These data show that IL-17 may have a role in priming for enhanced chemokine and G-CSF production in the context of lung infection and that optimally timed gene therapy with IL-17 may augment host defense against bacterial pneumonia.

Abbreviations: antibody, Ab; a recombinant adenovirus encoding murine IL-17, AdIL-17; absolute neutrophil count, ANC; analysis of variance, ANOVA; bronchoalveolar lavage fluid, BALF; colony-forming units, CFU; enzyme-linked immunosorbent assay, ELISA; granulocyte colony-stimulating factor, G-CSF; intratracheal, i.t., interleukin, IL; macrophage inflammatory protein, MIP; phosphate-buffered saline, PBS; plaque-forming units, PFU; polymorphonuclear leukocyte, PMN; tumor necrosis factor, TNF.




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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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Home page
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