help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chan, E. D.
Right arrow Articles by Schluger, N. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chan, E. D.
Right arrow Articles by Schluger, N. W.

Am. J. Respir. Cell Mol. Biol., Volume 25, Number 5, November, 2001 606-612

What is the Role of Nitric Oxide in Murine and Human Host Defense against Tuberculosis?
Current Knowledge

Edward D. Chan, John Chan, and Neil W. Schluger

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center and Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado; Department of Medicine, Albert Einstein School of Medicine, Bronx, New York; and Division of Pulmonary and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, New York

The production of reactive oxygen intermediates and reactive nitrogen intermediates by innate immune cells is considered to be an effective host-defense mechanism against microbial pathogens. In the murine model of tuberculosis (TB), nitric oxide (NO) plays an essential role in the killing of Mycobacterium tuberculosis by mononuclear phagocytes. For example, in the mouse strain with a genetic disruption for inducible NO synthase (iNOS-/-), infection with M. tuberculosis is associated with a significantly higher risk of dissemination and mortality. Although more controversial in humans, there is a growing body of evidence that NO produced by TB-infected macrophages and by epithelial cells also has antimycobacterial effects against M. tuberculosis. The precise mechanism(s) by which NO and other reactive nitrogen species antagonize M. tuberculosis is not known, but may involve disruption of bacterial DNA, proteins, signaling, and/or induction of apoptosis of macrophages that harbor mycobacteria. In addition to cytokines such as tumor necrosis factor-alpha and interleukin 1-beta , mycobacterial cell wall components such as lipoarabinomannan and 19 kD lipoprotein, along with the T-cell-derived interferon-gamma , may also induce NO expression. In a Darwinian fashion, it also appears that certain strains of M. tuberculosis have evolved strategies to combat the toxic effects of NO.

Abbreviations: dendritic cells, DC; interferon, IFN; interleukin, IL; inducible nitric oxide synthase, iNOS; lipomannan, LAM; mannose-capped lipoarabinomannan, ManLAM; nitric oxide, NO; nitrogen dioxide, NO2; superoxide anion, O2-; peroxynitrite anion, ONOO-; dimannosylphosphatidylinositides, PIM2; reactive nitrogen intermediates, RNI; reactive oxygen intermediates, ROI; tuberculosis, TB; tumor necrosis factor, TNF.




This article has been cited by other articles:


Home page
 MicrobiologyHome page
K. R. Barth, V. M. Isabella, L. F. Wright, and V. L. Clark
Resistance to peroxynitrite in Neisseria gonorrhoeae
Microbiology, August 1, 2009; 155(8): 2532 - 2545.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
M. B. Mowa, D. F. Warner, G. Kaplan, B. D. Kana, and V. Mizrahi
Function and Regulation of Class I Ribonucleotide Reductase-Encoding Genes in Mycobacteria
J. Bacteriol., February 1, 2009; 191(3): 985 - 995.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
S. Schmidt, T. H. Westhoff, P. Krauser, R. Ignatius, J. Jankowski, V. Jankowski, W. Zidek, and M. van der Giet
The uraemic toxin phenylacetic acid impairs macrophage function
Nephrol. Dial. Transplant., November 1, 2008; 23(11): 3485 - 3493.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. O. Jurado, I. B. Alvarez, V. Pasquinelli, G. J. Martinez, M. F. Quiroga, E. Abbate, R. M. Musella, H. E. Chuluyan, and V. E. Garcia
Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis
J. Immunol., July 1, 2008; 181(1): 116 - 125.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
C. D. Sohaskey
Nitrate Enhances the Survival of Mycobacterium tuberculosis during Inhibition of Respiration
J. Bacteriol., April 15, 2008; 190(8): 2981 - 2986.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
L. H. Ly, M. I. Russell, and D. N. McMurray
Cytokine Profiles in Primary and Secondary Pulmonary Granulomas of Guinea Pigs with Tuberculosis
Am. J. Respir. Cell Mol. Biol., April 1, 2008; 38(4): 455 - 462.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
M. Niederweis
Nutrient acquisition by mycobacteria
Microbiology, March 1, 2008; 154(3): 679 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Kumar, L. D. Hazlett, and F.-S. X. Yu
Flagellin Suppresses the Inflammatory Response and Enhances Bacterial Clearance in a Murine Model of Pseudomonas aeruginosa Keratitis
Infect. Immun., January 1, 2008; 76(1): 89 - 96.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. Engel, U. Dobrindt, A. Tittel, P. Peters, J. Maurer, I. Gutgemann, B. Kaissling, W. Kuziel, S. Jung, and C. Kurts
Tumor Necrosis Factor Alpha- and Inducible Nitric Oxide Synthase-Producing Dendritic Cells Are Rapidly Recruited to the Bladder in Urinary Tract Infection but Are Dispensable for Bacterial Clearance
Infect. Immun., November 1, 2006; 74(11): 6100 - 6107.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Breitbach, S. Klocke, T. Tschernig, N. van Rooijen, U. Baumann, and I. Steinmetz
Role of Inducible Nitric Oxide Synthase and NADPH Oxidase in Early Control of Burkholderia pseudomallei Infection in Mice
Infect. Immun., November 1, 2006; 74(11): 6300 - 6309.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Loeuillet, F. Martinon, C. Perez, M. Munoz, M. Thome, and P. R. Meylan
Mycobacterium tuberculosis Subverts Innate Immunity to Evade Specific Effectors
J. Immunol., November 1, 2006; 177(9): 6245 - 6255.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
T. D. Sirakova, V. S. Dubey, C. Deb, J. Daniel, T. A. Korotkova, B. Abomoelak, and P. E. Kolattukudy
Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress.
Microbiology, September 1, 2006; 152(Pt 9): 2717 - 2725.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
M. T. Talaue, V. Venketaraman, M. H. Hazbon, M. Peteroy-Kelly, A. Seth, R. Colangeli, D. Alland, and N. D. Connell
Arginine Homeostasis in J774.1 Macrophages in the Context of Mycobacterium bovis BCG Infection
J. Bacteriol., July 1, 2006; 188(13): 4830 - 4840.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. F. Quiroga, V. Pasquinelli, G. J. Martinez, J. O. Jurado, L. C. Zorrilla, R. M. Musella, E. Abbate, P. A. Sieling, and V. E. Garcia
Inducible Costimulator: A Modulator of IFN-{gamma} Production in Human Tuberculosis
J. Immunol., May 15, 2006; 176(10): 5965 - 5974.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. Tjarnlund, A. Rodriguez, P.-J. Cardona, E. Guirado, J. Ivanyi, M. Singh, M. Troye-Blomberg, and C. Fernandez
Polymeric IgR knockout mice are more susceptible to mycobacterial infections in the respiratory tract than wild-type mice
Int. Immunol., May 1, 2006; 18(5): 807 - 816.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
Y. K. Dayaram, M. T. Talaue, N. D. Connell, and V. Venketaraman
Characterization of a Glutathione Metabolic Mutant of Mycobacterium tuberculosis and Its Resistance to Glutathione and Nitrosoglutathione
J. Bacteriol., February 15, 2006; 188(4): 1364 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
Y. Yuhas, E. Berent, H. Ovadiah, I. Azoulay, and S. Ashkenazi
Rifampin Augments Cytokine-Induced Nitric Oxide Production in Human Alveolar Epithelial Cells
Antimicrob. Agents Chemother., January 1, 2006; 50(1): 396 - 398.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Tomioka, C. Sano, K. Sato, K. Ogasawara, T. Akaki, K. Sano, S. S. Cai, and T. Shimizu
Combined Effects of ATP on the Therapeutic Efficacy of Antimicrobial Drug Regimens against Mycobacterium avium Complex Infection in Mice and Roles of Cytosolic Phospholipase A2-Dependent Mechanisms in the ATP-Mediated Potentiation of Antimycobacterial Host Resistance
J. Immunol., November 15, 2005; 175(10): 6741 - 6749.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
C. D. Sohaskey
Regulation of nitrate reductase activity in Mycobacterium tuberculosis by oxygen and nitric oxide
Microbiology, November 1, 2005; 151(11): 3803 - 3810.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
J. Hostetter, E. Huffman, K. Byl, and E. Steadham
Inducible Nitric Oxide Synthase Immunoreactivity in the Granulomatous Intestinal Lesions of Naturally Occurring Bovine Johne's Disease
Vet. Pathol., May 1, 2005; 42(3): 241 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. T. Chang, J. J. Linderman, and D. E. Kirschner
Multiple mechanisms allow Mycobacterium tuberculosis to continuously inhibit MHC class II-mediated antigen presentation by macrophages
PNAS, March 22, 2005; 102(12): 4530 - 4535.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
R. Long, R. Jones, J. Talbot, I. Mayers, J. Barrie, M. Hoskinson, and B. Light
Inhaled Nitric Oxide Treatment of Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears
Antimicrob. Agents Chemother., March 1, 2005; 49(3): 1209 - 1212.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. Venketaraman, Y. K. Dayaram, M. T. Talaue, and N. D. Connell
Glutathione and Nitrosoglutathione in Macrophage Defense against Mycobacterium tuberculosis
Infect. Immun., March 1, 2005; 73(3): 1886 - 1889.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. B. Torrelles, K.-H. Khoo, P. A. Sieling, R. L. Modlin, N. Zhang, A. M. Marques, A. Treumann, C. D. Rithner, P. J. Brennan, and D. Chatterjee
Truncated Structural Variants of Lipoarabinomannan in Mycobacterium leprae and an Ethambutol-resistant Strain of Mycobacterium tuberculosis
J. Biol. Chem., September 24, 2004; 279(39): 41227 - 41239.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
J. Daniel, C. Deb, V. S. Dubey, T. D. Sirakova, B. Abomoelak, H. R. Morbidoni, and P. E. Kolattukudy
Induction of a Novel Class of Diacylglycerol Acyltransferases and Triacylglycerol Accumulation in Mycobacterium tuberculosis as It Goes into a Dormancy-Like State in Culture
J. Bacteriol., August 1, 2004; 186(15): 5017 - 5030.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Botha and B. Ryffel
Reactivation of Latent Tuberculosis Infection in TNF-Deficient Mice
J. Immunol., September 15, 2003; 171(6): 3110 - 3118.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
R. Ciccone, F. Mariani, A. Cavone, T. Persichini, G. Venturini, E. Ongini, V. Colizzi, and M. Colasanti
Inhibitory Effect of NO-Releasing Ciprofloxacin (NCX 976) on Mycobacterium tuberculosis Survival
Antimicrob. Agents Chemother., July 1, 2003; 47(7): 2299 - 2302.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Schon, D. Elias, F. Moges, E. Melese, T. Tessema, O. Stendahl, S. Britton, and T. Sundqvist
Arginine as an adjuvant to chemotherapy improves clinical outcome in active tuberculosis
Eur. Respir. J., March 1, 2003; 21(3): 483 - 488.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H.-S. Choi, P. R. Rai, H. W. Chu, C. Cool, and E. D. Chan
Analysis of Nitric Oxide Synthase and Nitrotyrosine Expression in Human Pulmonary Tuberculosis
Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 178 - 186.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Ouellet, Y. Ouellet, C. Richard, M. Labarre, B. Wittenberg, J. Wittenberg, and M. Guertin
Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide
PNAS, April 10, 2002; (2002) 92017799.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Ouellet, Y. Ouellet, C. Richard, M. Labarre, B. Wittenberg, J. Wittenberg, and M. Guertin
Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide
PNAS, April 30, 2002; 99(9): 5902 - 5907.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 2001 American Thoracic Society. 		  Tobacco