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Published ahead of print on December 30, 2004, doi:10.1165/rcmb.2004-0197OC
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American Journal of Respiratory Cell and Molecular Biology. Vol. 32, pp. 201-210, 2005
© 2005 American Thoracic Society
DOI: 10.1165/rcmb.2004-0197OC

Mycoplasma pneumoniae Induces Host-Dependent Pulmonary Inflammation and Airway Obstruction in Mice

Monica Fonseca-Aten, Ana M. Ríos, Asunción Mejías, Susana Chávez-Bueno, Kathy Katz, Ana M. Gómez, George H. McCracken, Jr. and R. Doug Hardy

Departments of Pediatrics, Internal Medicine, and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas

Correspondence and requests for reprints should be addressed to Monica Fonseca-Aten, M.D, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063. E-mail address: Monica.Fonseca-Aten{at}utsouthwestern.edu

Respiratory tract infections result in wheezing in a subset of patients. Mycoplasma pneumoniae is a common etiologic agent of acute respiratory infection in children and adults that has been associated with wheezing in 20–40% of individuals. The current study was undertaken to elucidate the host-dependent pulmonary and immunologic response to M. pneumoniae respiratory infection by studying mice with different immunogenetic backgrounds (BALB/c mice versus C57BL/6 mice). After M. pneumoniae infection, only BALB/c mice developed significant airway obstruction (AO) compared with controls. M. pneumoniae–infected BALB/c mice manifested significantly elevated airway hyperresponsiveness (AHR) compared with C57BL/6 mice 4 and 7 d after inoculation as well as BALB/c control mice. Compared with C57BL/6 mice, BALB/c mice developed worse pulmonary inflammation, including greater peribronchial infiltrates. Infected BALB/c mice had significantly higher concentrations of tumor necrosis factor-{alpha}, interferon-{gamma}, interleukin (IL)-1ß, IL-6, IL-12, KC (functional IL-8), and macrophage inflammatory protein 1{alpha} in the bronchoalveolar lavage fluid compared with infected C57BL/6 mice. No differences in IL-2, IL-4, IL-5, IL-10, and granulocyte/macrophage colony-stimulating factor concentrations were found. The mice in this study exhibited host-dependent infection-related AO and AHR associated with chemokine and T-helper type (Th)1 pulmonary host response and not Th2 response after M. pneumoniae infection.

Key Words: Mycoplasma pneumoniae • airway obstruction • asthma • airway hyperresponsiveness • cytokines • chemokines




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