help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on December 30, 2004, doi:10.1165/rcmb.2004-0058OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2004-0058OCv1
32/4/268    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ito, W.
Right arrow Articles by Tanimoto, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ito, W.
Right arrow Articles by Tanimoto, M.
American Journal of Respiratory Cell and Molecular Biology. Vol. 32, pp. 268-280, 2005
© 2005 American Thoracic Society
DOI: 10.1165/rcmb.2004-0058OC

Hepatocyte Growth Factor Attenuates Airway Hyperresponsiveness, Inflammation, and Remodeling

Wataru Ito, Arihiko Kanehiro, Kunio Matsumoto, Atsushi Hirano, Katsuichiro Ono, Hiromi Maruyama, Mikio Kataoka, Toshikazu Nakamura, Erwin W. Gelfand and Mitsune Tanimoto

Second Department of Internal Medicine, Okayama University Medical School, Okayama; Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka, Japan; and Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado

Correspondence and requests for reprints should be addressed to Arihiko Kanehiro, M.D., Second Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. E-mail: akanehir{at}md.okayama-u.ac.jp

Hepatocyte growth factor (HGF) is known to influence a number of cell types and their production of regulatory cytokines. We investigated the potential of recombinant HGF to regulate not only the development of allergic airway inflammation and airway hyperresponsiveness (AHR), but also airway remodeling in a murine model. Administration of exogenous HGF after sensitization but during ovalbumin challenge significantly prevented AHR, as well as eosinophil and lymphocyte accumulation in the airways; interleukin (IL)-4, IL-5, and IL-13 levels in bronchoalveolar lavage (BAL) fluid were also significantly reduced. Further, treatment with HGF significantly suppressed transforming growth factor-ß (TGF-ß), platelet-derived growth factor, and nerve growth factor levels in BAL fluid. The expression of TGF-ß, the development of goblet cell hyperplasia and subepithelial collagenization, and the increases in contractile elements in the lung were also reduced by recombinant HGF. Neutralization of endogenous HGF resulted in increased AHR as well as the number of eosinophils, levels of Th2 cytokines (IL-4, IL-5, and IL-13) and TGF-ß in BAL fluid. These data indicate that HGF may play an important role in the regulation of allergic airway inflammation, hyperresponsiveness, and remodeling.

Key Words: airway hyperresponsiveness • airway inflammation • airway remodeling • hepatocyte growth factor • transforming growth factor-ß




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Kuramoto, T. Nishiuma, K. Kobayashi, M. Yamamoto, Y. Kono, Y. Funada, Y. Kotani, T. H. Sisson, R. H. Simon, and Y. Nishimura
Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model
Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L337 - L346.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Gong, A. Rifai, Y. Ge, S. Chen, and L. D. Dworkin
Hepatocyte Growth Factor Suppresses Proinflammatory NF{kappa}B Activation through GSK3{beta} Inactivation in Renal Tubular Epithelial Cells
J. Biol. Chem., March 21, 2008; 283(12): 7401 - 7410.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Okunishi, M. Dohi, K. Fujio, K. Nakagome, Y. Tabata, T. Okasora, M. Seki, M. Shibuya, M. Imamura, H. Harada, et al.
Hepatocyte Growth Factor Significantly Suppresses Collagen-Induced Arthritis in Mice
J. Immunol., October 15, 2007; 179(8): 5504 - 5513.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. Hirano, A. Kanehiro, K. Ono, W. Ito, A. Yoshida, C. Okada, H. Nakashima, Y. Tanimoto, M. Kataoka, E. W. Gelfand, et al.
Pirfenidone Modulates Airway Responsiveness, Inflammation, and Remodeling after Repeated Challenge
Am. J. Respir. Cell Mol. Biol., September 1, 2006; 35(3): 366 - 377.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
R. Gong, A. Rifai, and L. D. Dworkin
Anti-Inflammatory Effect of Hepatocyte Growth Factor in Chronic Kidney Disease: Targeting the Inflamed Vascular Endothelium
J. Am. Soc. Nephrol., September 1, 2006; 17(9): 2464 - 2473.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. W. Raymond, A. C. Cruz, and G. H. Caughey
Mast Cell and Neutrophil Peptidases Attack an Inactivation Segment in Hepatocyte Growth Factor to Generate NK4-like Antagonists
J. Biol. Chem., January 20, 2006; 281(3): 1489 - 1494.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 2005 American Thoracic Society. 		  SOTA, FL