help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published ahead of print on June 16, 2005, doi:10.1165/rcmb.2005-0003OC
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2005-0003OCv1
33/3/290    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kang, C.-M.
Right arrow Articles by Park, C.-S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kang, C.-M.
Right arrow Articles by Park, C.-S.
American Journal of Respiratory Cell and Molecular Biology. Vol. 33, pp. 290-296, 2005
© 2005 American Thoracic Society
DOI: 10.1165/rcmb.2005-0003OC

Interleukin-25 and Interleukin-13 Production by Alveolar Macrophages in Response to Particles

Chun-Mi Kang*, An-Soo Jang*, Mi-Hyun Ahn, Jeong-Ah Shin, Ji-Hye Kim, Yun-Sung Choi, Tai-Youn Rhim and Choon-Sik Park

Genome Research Center for Allergy and Respiratory Diseases, and Division of Allergy and Respiratory Diseases, Soonchunhyang University Hospital, Bucheon, Republic of Korea

Correspondence and requests for reprints should be addressed to Dr. Choon-Sik Park, Division of Allergy and Respiratory Diseases, Department of Internal Medicine, Soonchunhyang University Hospital, 1174, Jung-dong, Wonmi-gu, Bucheon-si, Gyeonggido 420-767, Republic of Korea. E-mail: mdcspark{at}unitel.co.kr

Particle inhalation–induced lung inflammation acts as an adjuvant to allergens or respiratory viral infection in a process that is mediated by macrophages and epitheliums. The production of interleukin (IL)-4 and IL-13 by activated T cells is involved in the augmentation of Th2-type immune responses to particles, and IL-25 induces the synthesis of IL-4 and IL-13. However, whether IL-13 and IL-25 are directly regulated by particle instillation in the lung has not been studied. The aim of this study was to reveal particle induction of IL-13 and IL-25 in the lung. TiO2 instillation potently induced the mRNA expression for IL-25 and IL-13 in lung tissue extracts 24 h after treatment, as compared with the sham group. Immunostaining for IL-25 and IL-13 showed strong positivity for macrophages in the inflammatory lung lesions of TiO2-treated rats. The alveolar macrophages expressed IL-25 and IL-13 24 h after in vitro stimulation with TiO2 particles in dose- and time-dependent manners, with maximal induction at 24 and 48 h after stimulation, respectively. The sequence of the rat IL-25 gene is 95% homologous with the mouse IL-25 gene. These findings indicate that alveolar macrophages play an important role in particle-induced lung inflammation via direct induction of IL-13 and IL-25 production.

Key Words: cytokines • inflammation • lung • macrophages




This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. V. Fedulov, A. Leme, Z. Yang, M. Dahl, R. Lim, T. J. Mariani, and L. Kobzik
Pulmonary Exposure to Particles during Pregnancy Causes Increased Neonatal Asthma Susceptibility
Am. J. Respir. Cell Mol. Biol., January 1, 2008; 38(1): 57 - 67.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. A. Kleinschek, A. M. Owyang, B. Joyce-Shaikh, C. L. Langrish, Y. Chen, D. M. Gorman, W. M. Blumenschein, T. McClanahan, F. Brombacher, S. D. Hurst, et al.
IL-25 regulates Th17 function in autoimmune inflammation
J. Exp. Med., January 22, 2007; 204(1): 161 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
M.-H. Cha, T. Rhim, K. H. Kim, A.-S. Jang, Y.-K. Paik, and C.-S. Park
Proteomic Identification of Macrophage Migration-inhibitory Factor upon Exposure to TiO2 Particles
Mol. Cell. Proteomics, January 1, 2007; 6(1): 56 - 63.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Lajoie-Kadoch, P. Joubert, S. Letuve, A. J. Halayko, J. G. Martin, A. Soussi-Gounni, and Q. Hamid
TNF-{alpha} and IFN-{gamma} inversely modulate expression of the IL-17E receptor in airway smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, June 1, 2006; 290(6): L1238 - L1246.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 2005 American Thoracic Society.