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Regulation of Mucin Genes in Chronic Inflammatory Airway Diseases

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina; Department of Biochemistry/Molecular Biology and Tumor Biology Program, Mayo Clinic College of Medicine, Scottsdale, Arizona; and Research Center for Genetic Medicine, Children's National Medical Center and Departments of Pediatrics and Biochemistry/Molecular Biology, George Washington University, Washington, D.C.

Correspondence and requests for reprints should be addressed to Judith A. Voynow, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710. E-mail: voyno001{at}mc.duke.edu

Abstract

In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding the basic pathogenic mechanisms that drive mucus overproduction in cystic fibrosis, chronic obstructive pulmonary disease, and asthma.

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