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Published ahead of print on June 2, 2009, doi:10.1165/rcmb.2009-0122RC
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American Journal of Respiratory Cell and Molecular Biology. Vol. 41, pp. 379-384, 2009
© 2009 American Thoracic Society
DOI: 10.1165/rcmb.2009-0122RC

Rapid Communication

Macrophage Chitinase 1 Stratifies Chronic Obstructive Lung Disease

Eugene Agapov1, John T. Battaile1, Rose Tidwell1, Ramsey Hachem1, G. Alexander Patterson2, Richard A. Pierce1, Jeffrey J. Atkinson1 and Michael J. Holtzman1,3

1 Department of Medicine, 2 Department of Surgery, and 3 Department of Cell Biology, Washington University School of Medicine, St. Louis, Missouri

Correspondence and requests for reprints should be addressed to Michael J. Holtzman, M.D., Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail: holtzmanm{at}wustl.edu.

Diagnosis and therapy of chronic inflammatory lung disease is limited by the need for individualized biomarkers that provide insight into pathogenesis. Herein we show that mouse models of chronic obstructive lung disease exhibit an increase in lung chitinase production but cannot predict which chitinase family member may be equivalently increased in humans with corresponding lung disease. Moreover, we demonstrate that lung macrophage production of chitinase 1 is selectively increased in a subset of subjects with severe chronic obstructive pulmonary disease, and this increase is reflected in plasma levels. The findings provide a means to noninvasively track alternatively activated macrophages in chronic lung disease and thereby better differentiate molecular phenotypes in heterogeneous patient populations.


CLINICAL RELEVANCE

The research findings provide a new means to noninvasively track the type of inflammation that occurs in chronic obstructive lung disease and thereby better guide diagnosis and treatment for this disease process.

 

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AJRCMB 2009 41: 377-378. [Full Text]  



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 Am. J. Respir. Cell Mol. Bio.Home page
K. B. Adler and S. Matalon
Highlights of the October Issue
Am. J. Respir. Cell Mol. Biol., October 1, 2009; 41(4): 377 - 378.
[Full Text] [PDF]


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