© 2006 American Thoracic Society DOI: 10.1165/rcmb.F320
Clinical Use of Normobaric HyperoxiaDepartment of Anesthesiology and Reanimation, Hospital General Universitario de Elche, Spain To the Editor: I read with interest the recent paper of Brueckl and colleagues (1) about hyperoxia-induced reactive oxygen species formation in pulmonary capillary endothelial cells. The authors state that "clinical use of normobaric hyperoxia for several hours is frequently considered harmless or even recommended," and cite two studies which found that 80% oxygen could reduce surgical site infection versus 30% oxygen (2, 3). However, these two studies have not shown any improvement among clinically valuable outcomes (mortality, postoperative stay, time to first solid food intake, walking, or staples removed). Moreover, another study comparing 80% oxygen versus 35% oxygen found deleterious effects of normobaric hyperoxia (4). The clinical use of normobaric hyperoxia to reduce surgical site infection remains a matter of debate. Furthermore, data evaluating more moderate oxygen concentrations (45–60%) are not currently available (5). Footnotes Conflict of Interest Statement: The author does not have a financial relationship with a commercial entity that has an interest in the subject of this manuscript. References
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
