© 2008 American Thoracic Society
Erratum: Epithelium Expression and Function of Retinoid Receptors in Asthma
Faculté de Médecine Necker To the Editor: The article "Epithelium Expression and Function of Retinoid Receptors in Asthma," published in the March issue of AJRCMB (1), omitted three tables and their accompanying text citations. The omitted tables are presented below, with text citations in bold. On page 277, the text in the first paragraph of MATERIALS AND METHODS that refers to Table 1 should read:
"Nine healthy volunteers, 10 subjects with intermittent asthma, 8 subjects with mild-to-moderate persistent asthma, and 10 subjects with severe persistent asthmatics fulfilling National Institutes of Health criteria (15) were recruited (Table 1)." On page 278, the text of the second paragraph of EXPRESSION OF RETINOID RECEPTORS IN CULTURED AIRWAY EPITHELIAL CELLS that refers to Table 2 should read:
"Under the same conditions, ATRA and 9-cis RA (1 µM) increased respectively by 6.3- and 7.9-fold RARβ mRNA and decreased RAR  mRNA expression, without altering the levels of the transcripts encoding the other receptors analyzed (Table 2). Finally, TGF-β1 augmented by 2.1-fold and reduced by 0.4-fold the expression of RAR and RAR, respectively (Table 2)." On page 279, the text of the first and second paragraphs of EFFECT OF RETINOIDS ON THE SYNTHESIS OF FACTORS INVOLVED IN EPITHELIAL REPAIR AND IN AIRWAY REMODELING that refers to Table 3 should read:
"To determine whether ligation of retinoids to their receptors expressed by the asthmatic bronchial epithelium would participate in epithelial cell migration, in epithelium repair and in airway remodeling, we examined the ability of ATRA and of 9-cis RA to influence the synthesis of a number of factors involved in these processes (Table 3)... . By quantitative real-time PCR, we found detectable levels of the transcripts encoding MMP-1, -2, -9, and -12; tissue inhibitor of metalloproteinase-1, -2, -3, and -4; fibronectin; tenascin; β1-integrin; CD44; E-cadherin; β-catenin; EGF and its receptor; TGF- , -β1, and -2 and their receptor I and II; keratinocyte growth factor and its receptor 2; platelet-derived growth factor and β, insulin growth factor 1β and 2 and their receptor; endothelin-1, and hepatocyte growth factor receptor (HGF-R) (Table 3) in vehicle (DMSO)-stimulated human airway epithelial cells. The amounts of the transcripts of MMP-7, collagen type I1, insulin growth factor 1, and platelet-derived growth factor receptors and β, were very low, and they were found in three or four out of the five cell preparations (Table 3). Finally, HGF and endothelin-1 receptors A and B were undetectable in all samples tested (Table 3). "Incubation of airway epithelial cells during 48 hours with 1 µM of ATRA or 9-cis RA augmented the levels of the transcripts encoding TGF-β1, MMP-9, HGF-R, and β1-integrin, without changes in the amounts of mRNA for the other factors analyzed (Table 3 and Figure 3)." Footnotes Conflict of Interest Statement: The author does not have a financial relationship with a commercial entity that has an interest in the subject of this manuscript. Editor's Note: A complete pdf of the corrected article, including tables and text citations, is available as an online supplement to the original article in the March 2008 issue of AJRCMB. References
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