Published ahead of print on February 21, 2003, doi:10.1165/rcmb.2002-0269OC Am. J. Respir. Cell Mol. Biol., Volume 29, Number 2, August 2003, 180-187 A more recent version of this article appeared on August 1, 2003
Submitted on December 3, 2002 PM INDUCES AEC DNA DAMAGE AND APOPTOSIS: ROLE OF FREE RADICALS AND THE MITOCHONDRIADaya Upadhyay1,1 Pulmonary and Critical Care Medicine, Northwestern University Medical School, Chicago, Illinois, USA, 2 Pulmonary and Critical Care Medicine, NHEERL, EPA, Research Triangle Park, NC, USA, 3 Pulmonary and Critical Care Medicine, Northwestern University Medical School, Chicago, Illinois, USA; Department of Medicine, Veterans Administration Chicago Health Care System: Lakeside Division, Chicago, Illinois, USA * To whom correspondence should be addressed. E-mail: d-kamp{at}northwestern.edu.
Airborne particulate matter (PM) increases morbidity and mortality resulting from cardiopulmonary diseases including cancer. We hypothesized that PM is genotoxic to AEC by causing DNA damage and apoptosis. PM caused dose-dependent
AEC DNA strand break formation, reductions in mitochondrial
membrane potential (
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