help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on April 29, 2004, doi:10.1165/rcmb.2003-0319OC

Am. J. Respir. Cell Mol. Biol., Volume 31, Number 3, September 2004, 276-282

A more recent version of this article appeared on September 1, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2003-0319OCv1
31/3/276    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wagner, K. F
Right arrow Articles by Li, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wagner, K. F
Right arrow Articles by Li, D.

Submitted on August 28, 2003
Revised on April 28, 2004

HIMF has anti-apoptotic action and is upregulated in developing lung: co-expression with HIF-2{alpha}

Klaus F Wagner1, Ann-Katrin Hellberg1, Susan Balenger2, Reinhard Depping2, Jeffrey Dodd-O2, Roger A Johns2, and Dechun Li2*

1 Department of Anesthesiology, University of Lubeck, Lubeck, Germany, 2 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: dechunli{at}jhmi.edu.

Hypoxia-induced mitogenic factor (HIMF), also called FIZZ1 or RELM{alpha} was a newly found cytokine. Hypoxia caused robust HIMF induction in the lung and HIMF has potent pulmonary vasoconstrictive, proliferative and angiogenic properties. To investigate the role of HIMF in lung development, we determined its spatial and temporal expression. From embryonic day 16 (E16) to postnatal day 28 (P28), HIMF was strongly expressed in the cytoplasm of bronchial epithelial cells, type II cells, endothelial cells, and primitive mesenchymal cells. Treatment with HIMF resulted in a significant reduction of apoptosis in cultured embryonic lung, thus revealing a previously unknown function of HIMF. Since HIMF gene is up-regulated by hypoxia and contains a hypoxia-inducible transcription factor (HIF) binding site we subsequently investigated whether HIMF was co-expressed with HIF-2{alpha} or HIF-1 {alpha}. HIF-1{alpha} expression was temporally distinct from HIMF expression. In contrast, HIF-2{alpha} was present in endothelial cells, bronchial epithelial and type II cells from E18 to P28. Thus, HIMF and HIF-2{alpha} were temporally and spatially co-expressed in the developing lung. These results indicate a role for HIMF in lung development, possibly under the control of HIF-2, and suggest that HIMF regulates apoptosis and may participate in lung alveolarization and maturation.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
Y. Maeda, T. Suzuki, X. Pan, G. Chen, S. Pan, T. Bartman, and J. A. Whitsett
CUL2 Is Required for the Activity of Hypoxia-inducible Factor and Vasculogenesis
J. Biol. Chem., June 6, 2008; 283(23): 16084 - 16092.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Q. Zhang, D. J. Bellotto, P. Ravikumar, O. W. Moe, R. T. Hogg, D. C. Hogg, A. S. Estrera, R. L. Johnson Jr., and C. C. W. Hsia
Postpneumonectomy lung expansion elicits hypoxia-inducible factor-1{alpha} signaling
Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L497 - L504.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Q. Su, Y. Zhou, and R. A. Johns
Bruton's tyrosine kinase (BTK) is a binding partner for hypoxia induced mitogenic factor (HIMF/FIZZ1) and mediates myeloid cell chemotaxis
FASEB J, May 1, 2007; 21(7): 1376 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
I. Kojima, T. Tanaka, R. Inagi, H. Kato, T. Yamashita, A. Sakiyama, O. Ohneda, N. Takeda, M. Sata, T. Miyata, et al.
Protective Role of Hypoxia-Inducible Factor-2{alpha} against Ischemic Damage and Oxidative Stress in the Kidney
J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1218 - 1226.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
Y. Maeda, V. Dave, and J. A. Whitsett
Transcriptional Control of Lung Morphogenesis
Physiol Rev, January 1, 2007; 87(1): 219 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Yamaji-Kegan, Q. Su, D. J. Angelini, H. C. Champion, and R. A. Johns
Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2
Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1159 - L1168.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Q. Tong, L. Zheng, L. Lin, B. Li, D. Wang, and D. Li
Hypoxia-Induced Mitogenic Factor Promotes Vascular Adhesion Molecule-1 Expression via the PI-3K/Akt-NF-{kappa}B Signaling Pathway
Am. J. Respir. Cell Mol. Biol., October 1, 2006; 35(4): 444 - 456.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Q. Zhang, O. W. Moe, J. A. Garcia, and C. C. W. Hsia
Regulated expression of hypoxia-inducible factors during postnatal and postpneumonectomy lung growth
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L880 - L889.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Q. Tong, L. Zheng, J. Dodd-o, J. Langer, D. Wang, and D. Li
Hypoxia-Induced Mitogenic Factor Modulates Surfactant Protein B and C Expression in Mouse Lung
Am. J. Respir. Cell Mol. Biol., January 1, 2006; 34(1): 28 - 38.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. Li, L. G. Fernandez, J. Dodd-o, J. Langer, D. Wang, and V. E. Laubach
Upregulation of Hypoxia-Induced Mitogenic Factor in Compensatory Lung Growth after Pneumonectomy
Am. J. Respir. Cell Mol. Biol., March 1, 2005; 32(3): 185 - 191.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. G. Nair, I. J. Gallagher, M. D. Taylor, P. Loke, P. S. Coulson, R. A. Wilson, R. M. Maizels, and J. E. Allen
Chitinase and Fizz Family Members Are a Generalized Feature of Nematode Infection with Selective Upregulation of Ym1 and Fizz1 by Antigen-Presenting Cells
Infect. Immun., January 1, 2005; 73(1): 385 - 394.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 2004 American Thoracic Society.