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Published ahead of print on July 29, 2004, doi:10.1165/rcmb.2004-0008OC

Am. J. Respir. Cell Mol. Biol., Volume 31, Number 6, December 2004, 595-600

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Submitted on January 8, 2004
Revised on July 26, 2004

Emphysema lung tissue gene expression profiling

Heiko A Golpon1, Christopher D Coldren2, Martin R Zamora2, Gregory P Cosgrove3, Mark D Moore2, Rubin M Tuder4, Mark W Geraci2, and Norbert F Voelkel2*

1 Department of Medicine, University of Magdeburg, Magdeburg, Germany, 2 Department of Medicine, University of Colorado, Denver, CO, USA, 3 Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA, 4 Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: Norbert.Voelkel{at}uchsc.edu.

Emphysema occurs in a subgroup of patients with chronic obstructive pulmonary disease (COPD) and patients with the genetic defect of Alpha1-Antitrypsin (AAT) Deficiency who have a smoking history of many years' duration. Emphysema is generally the result of a chronic and progressive destruction of the alveolar structures, which is believed to be driven by chronic inflammation, infections, oxidative stress, and an imbalance of protease and antiprotease activity. Here, we use microarray technology to characterize the gene expression profile of lung tissue samples obtained from patients with advanced emphysema and that of normal lung tissue. We hypothesized that the gene expression profile of emphysema lung tissue is distinct when compared with the expression profile of normal lungs. We report that severely emphysematous tissue is characterized by a global decrease in gene expression and by an increased abundance of transcripts encoding proteins involved in inflammation, immune responses and proteolysis. Whereas the gene expression profile is to some degree shared between 'usual' emphysema and AAT Deficiency-related emphysema, there are statistically significant differences in the modulation of groups of genes associated with protein and energy metabolism, and immune function, which allow distinction between these two emphysema types on the lung tissue level.




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