help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on December 30, 2004, doi:10.1165/rcmb.2004-0197OC

Am. J. Respir. Cell Mol. Biol., Volume 32, Number 3, March 2005, 201-210

A more recent version of this article appeared on March 1, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2004-0197OCv1
32/3/201    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fonseca-Aten, M.
Right arrow Articles by Hardy, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fonseca-Aten, M.
Right arrow Articles by Hardy, R. D.

Submitted on June 21, 2004
Revised on December 30, 2004

Mycoplasma pneumoniae Induces Host-Dependent Pulmonary Inflammation and Airway Obstruction in Mice

Monica Fonseca-Aten1*, Ana M Rios1, Asuncion Mejias1, Susana Chavez-Bueno1, Kathy Katz1, Ana M Gomez2, George H McCracken1, and R. Doug Hardy3

1 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA, 2 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA, 3 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA

* To whom correspondence should be addressed. E-mail: monica.fonseca-aten{at}utsouthwestern.edu.

Respiratory tract infections result in wheezing in a subset of patients. Mycoplasma pneumoniae is a common etiologic agent of acute respiratory infection in children and adults that has been associated with wheezing in 20% to 40% of individuals. The current study was undertaken to elucidate the host dependent pulmonary and immunologic response to M. pneumoniae respiratory infection by studying mice with different immunogenetic backgrounds (BALB/c mice versus C57BL/6 mice). After M. pneumoniae infection, only BALB/c mice developed significant airway obstruction (AO) compared with controls. M. pneumoniae infected-BALB/c mice manifested significantly elevated airway hyperresponsiveness (AHR) compared with C57BL/6 mice four and seven days post inoculation as well as BALB/c control mice. Compared with C57BL/6 mice, BALB/c mice developed worse pulmonary inflammation including greater peribronchial infiltrates. Infected BALB/c mice had significantly higher concentrations of tumor necrosis factor-{alpha}, interferon-{gamma}, interleukin (IL)-1{beta}, IL-6, IL-12, KC, and macrophage inflammatory protein 1{alpha} in the bronchoalveolar lavage fluid compared with infected C57BL/6 mice. No differences in IL-2, IL-4, IL-5, IL-10, and granulocyte/ macrophage colony-stimulating factor concentrations were found. The mice in this study exhibited host-dependent infection-related AO and AHR associated with chemokine and T-helper type (Th)1 pulmonary host response and not Th2 response after M. pneumoniae infection.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Chmura, X. Bai, M. Nakamura, P. Kandasamy, M. McGibney, K. Kuronuma, H. Mitsuzawa, D. R. Voelker, and E. D. Chan
Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells
Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L220 - L230.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. M. Salvatore, M. Fonseca-Aten, K. Katz-Gaynor, A. M. Gomez, and R. D. Hardy
Intranasal Interleukin-12 Therapy Inhibits Mycoplasma pneumoniae Clearance and Sustains Airway Obstruction in Murine Pneumonia
Infect. Immun., February 1, 2008; 76(2): 732 - 738.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
N. Miyashita, Y. Obase, K. Ouchi, K. Kawasaki, Y. Kawai, Y. Kobashi, and M. Oka
Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit
J. Med. Microbiol., December 1, 2007; 56(12): 1625 - 1629.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. M. Salvatore, M. Fonseca-Aten, K. Katz-Gaynor, A. M. Gomez, A. Mejias, C. Somers, S. Chavez-Bueno, G. H. McCracken, and R. D. Hardy
Respiratory Tract Infection with Mycoplasma pneumoniae in Interleukin-12 Knockout Mice Results in Improved Bacterial Clearance and Reduced Pulmonary Inflammation
Infect. Immun., January 1, 2007; 75(1): 236 - 242.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
I. Stelmach, M. Podsiadlowicz-Borzecka, T. Grzelewski, P. Majak, W. Stelmach, J. Jerzynska, M. Poplawska, and J. Dziadek
Humoral and Cellular Immunity in Children with Mycoplasma pneumoniae Infection: a 1-Year Prospective Study
Clin. Vaccine Immunol., October 1, 2005; 12(10): 1246 - 1250.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. M. Rios, M. Fonseca-Aten, A. Mejias, S. Chavez-Bueno, K. Katz, A. M. Gomez, G. H. McCracken Jr., O. Ramilo, and R. D. Hardy
Microbiologic and Immunologic Evaluation of a Single High Dose of Azithromycin for Treatment of Experimental Mycoplasma pneumoniae Pneumonia
Antimicrob. Agents Chemother., September 1, 2005; 49(9): 3970 - 3973.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 2004 American Thoracic Society.