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Published ahead of print on December 2, 2004, doi:10.1165/rcmb.2004-0304OC

Am. J. Respir. Cell Mol. Biol., Volume 32, Number 2, February 2005, 118-127

A more recent version of this article appeared on February 1, 2005
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Submitted on October 1, 2004
Revised on December 2, 2004

Developing rat lung has a sided pacemaker region for morphogenesis-related airway peristalsis

Edwin C Jesudason1*, Nicola P Smith1, Marilyn G Connell1, Dave G Spiller2, Mike R.H. White2, Dave G Fernig3, and Paul D Losty1

1 Department of Child Health, University of Liverpool, Liverpool, United Kingdom, 2 The Centre for Cell Imaging, University of Liverpool, Liverpool, United Kingdom, 3 The Molecular Medicine Group, University of Liverpool, Liverpool, United Kingdom

* To whom correspondence should be addressed. E-mail: e.jesudason{at}liv.ac.uk.

Prenatal airways from diverse species are capable of spontaneous peristaltic contractions in each trimester. The function of this smooth muscle activity is unknown. We demonstrate that peristalsis of the embryonic airway originates from a sided pacemaker focus, is stimulated in a calcium-dependent fashion by the pulmonary morphogen fibroblast growth factor-10 (FGF10) and appears coupled to lung growth. Airway peristalsis may be crucial for lung development (thereby providing a physiological role for airway smooth muscle) and play a hitherto unanticipated role in reported transgenic mutant lung phenotypes.




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