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Published ahead of print on February 2, 2006, doi:10.1165/rcmb.2006-0035SF

Am. J. Respir. Cell Mol. Biol., Volume 34, Number 6, June 2006, 661-665

A more recent version of this article appeared on June 1, 2006
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Submitted on January 26, 2006
Revised on February 2, 2006

Regulation of Mucin Genes in Chronic Inflammatory Airway Diseases

Judith A Voynow1*, Sandra J Gendler2, and Mary C Rose3

1 Department of Pediatrics, Duke University Medical Center, Durham, NC, USA, 2 Department of Biochemistry/Molecular Biology and Tumor Biology Program, Mayo Clinic College of Medicine, Scottsdale, AZ, USA, 3 Research Center for Genetic Medicine, and Departments of Pediatrics and Biochemistry/Molecular Biology, Children's National Medical Center and George Washington University, Washington D.C., USA

* To whom correspondence should be addressed. E-mail: voyno001{at}mc.duke.edu.

In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding the basic pathogenic mechanisms that drive mucus overproduction in cystic fibrosis, chronic obstructive pulmonary disease, and asthma.






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