help button home button
AJRCMB
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on February 2, 2006, doi:10.1165/rcmb.2006-0035SF

Am. J. Respir. Cell Mol. Biol., Volume 34, Number 6, June 2006, 661-665

A more recent version of this article appeared on June 1, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2006-0035SFv1
34/6/661    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Voynow, J. A
Right arrow Articles by Rose, M. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Voynow, J. A
Right arrow Articles by Rose, M. C

Submitted on January 26, 2006
Revised on February 2, 2006

Regulation of Mucin Genes in Chronic Inflammatory Airway Diseases

Judith A Voynow1*, Sandra J Gendler2, and Mary C Rose3

1 Department of Pediatrics, Duke University Medical Center, Durham, NC, USA, 2 Department of Biochemistry/Molecular Biology and Tumor Biology Program, Mayo Clinic College of Medicine, Scottsdale, AZ, USA, 3 Research Center for Genetic Medicine, and Departments of Pediatrics and Biochemistry/Molecular Biology, Children's National Medical Center and George Washington University, Washington D.C., USA

* To whom correspondence should be addressed. E-mail: voyno001{at}mc.duke.edu.

In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding the basic pathogenic mechanisms that drive mucus overproduction in cystic fibrosis, chronic obstructive pulmonary disease, and asthma.




This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J.-A. Park and D. J. Tschumperlin
Chronic Intermittent Mechanical Stress Increases MUC5AC Protein Expression
Am. J. Respir. Cell Mol. Biol., October 1, 2009; 41(4): 459 - 466.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S.-W. Park, C. Verhaeghe, L. T. Nguyenvu, R. Barbeau, C. J. Eisley, Y. Nakagami, X. Huang, P. G. Woodruff, J. V. Fahy, and D. J. Erle
Distinct Roles of FOXA2 and FOXA3 in Allergic Airway Disease and Asthma
Am. J. Respir. Crit. Care Med., October 1, 2009; 180(7): 603 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Wang, Y. Liu, L. Chen, X. Wang, X-R. Hu, Y-L. Feng, D-S. Liu, D. Xu, Y-P. Duan, J. Lin, et al.
Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats
Eur. Respir. J., May 1, 2009; 33(5): 1122 - 1132.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
L. Zhu, P.-k. Lee, W.-m. Lee, Y. Zhao, D. Yu, and Y. Chen
Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR-Dependent Pathway
Am. J. Respir. Cell Mol. Biol., May 1, 2009; 40(5): 610 - 619.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Abolhassani, A. Guais, P. Chaumet-Riffaud, A. J. Sasco, and L. Schwartz
Carbon dioxide inhalation causes pulmonary inflammation
Am J Physiol Lung Cell Mol Physiol, April 1, 2009; 296(4): L657 - L665.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. M. Casalino-Matsuda, M. E. Monzon, A. J. Day, and R. M. Forteza
Hyaluronan Fragments/CD44 Mediate Oxidative Stress-Induced MUC5B Up-Regulation in Airway Epithelium
Am. J. Respir. Cell Mol. Biol., March 1, 2009; 40(3): 277 - 285.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W.-C. Chung, S.-H. Ryu, H. Sun, D. C. Zeldin, and J. S. Koo
CREB Mediates Prostaglandin F2{alpha}-Induced MUC5AC Overexpression
J. Immunol., February 15, 2009; 182(4): 2349 - 2356.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. G. Lee, D. Hartl, H. Matsuura, F. M. Dunlop, P. D. Scotney, L. J. Fabri, A. D. Nash, N.-Y. Chen, C.-Y. Tang, Q. Chen, et al.
Endogenous IL-11 Signaling Is Essential in Th2- and IL-13-Induced Inflammation and Mucus Production
Am. J. Respir. Cell Mol. Biol., December 1, 2008; 39(6): 739 - 746.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Spiegl, S. Didichenko, P. McCaffery, H. Langen, and C. A. Dahinden
Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid
Blood, November 1, 2008; 112(9): 3762 - 3771.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Nakao, S. Kanaji, S. Ohta, H. Matsushita, K. Arima, N. Yuyama, M. Yamaya, K. Nakayama, H. Kubo, M. Watanabe, et al.
Identification of Pendrin as a Common Mediator for Mucus Production in Bronchial Asthma and Chronic Obstructive Pulmonary Disease
J. Immunol., May 1, 2008; 180(9): 6262 - 6269.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H. S. Deshmukh, C. Shaver, L. M. Case, M. Dietsch, S. C. Wesselkamper, W. D. Hardie, T. R. Korfhagen, M. Corradi, J. A. Nadel, M. T. Borchers, et al.
Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production
Am. J. Respir. Cell Mol. Biol., April 1, 2008; 38(4): 446 - 454.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Churg, M. Cosio, and J. L. Wright
Mechanisms of cigarette smoke-induced COPD: insights from animal models
Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L612 - L631.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y. Zhu, C. Ehre, L. H. Abdullah, J. K. Sheehan, M. Roy, C. M. Evans, B. F. Dickey, and C. W. Davis
Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways
J. Physiol., April 1, 2008; 586(7): 1977 - 1992.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
P H Tan, G M K Tse, and B H Bay
Mucinous breast lesions: diagnostic challenges
J. Clin. Pathol., January 1, 2008; 61(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. M. Munoz, A. Y. Meliton, J. P. Arm, J. V. Bonventre, W. Cho, and A. R. Leff
Deletion of Secretory Group V Phospholipase A2 Attenuates Cell Migration and Airway Hyperresponsiveness in Immunosensitized Mice
J. Immunol., October 1, 2007; 179(7): 4800 - 4807.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. H. Abdullah and C. W. Davis
Regulation of airway goblet cell mucin secretion by tyrosine phosphorylation signaling pathways
Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L591 - L599.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
T. Yoshida and R. M. Tuder
Pathobiology of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Physiol Rev, July 1, 2007; 87(3): 1047 - 1082.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. D. Rudd, M. A. Schaller, J. J. Smit, S. L. Kunkel, R. Neupane, L. Kelley, A. A. Berlin, and N. W. Lukacs
MyD88-Mediated Instructive Signals in Dendritic Cells Regulate Pulmonary Immune Responses during Respiratory Virus Infection
J. Immunol., May 1, 2007; 178(9): 5820 - 5827.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. O. Henke, G. John, M. Germann, H. Lindemann, and B. K. Rubin
MUC5AC and MUC5B Mucins Increase in Cystic Fibrosis Airway Secretions during Pulmonary Exacerbation
Am. J. Respir. Crit. Care Med., April 15, 2007; 175(8): 816 - 821.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
M. Li, J. R. Harkema, C. F. Cuff, and J. J. Pestka
Deoxynivalenol Exacerbates Viral Bronchopneumonia Induced by Respiratory Reovirus Infection
Toxicol. Sci., February 1, 2007; 95(2): 412 - 426.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. H. Randell
Airway Epithelial Stem Cells and the Pathophysiology of Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, November 1, 2006; 3(8): 718 - 725.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Li and L. A. Bobek
Functional Analysis of Human MUC7 Mucin Gene 5'-Flanking Region in Lung Epithelial Cells
Am. J. Respir. Cell Mol. Biol., November 1, 2006; 35(5): 593 - 601.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Crit. Care Med.
Copyright © 2006 American Thoracic Society. 		  ATS Coding and Billing Quarterly