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Published ahead of print on February 16, 2006, doi:10.1165/rcmb.2006-0047SF

Am. J. Respir. Cell Mol. Biol., Volume 34, Number 6, June 2006, 666-669

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Submitted on January 31, 2006
Revised on February 16, 2006

Oxidants and Signaling by Mitogen-Activated Protein Kinases (MAPK) in Lung Epithelium

Brooke T Mossman1*, Karen M Lounsbury2, and Sekhar P Reddy3

1 Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA, 2 Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT, USA, 3 Department of Environmental Health Sciences and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: Brooke.Mossman{at}uvm.edu.

Oxidants in cigarette smoke and generated from asbestos fibers activate mitogen-activated protein kinase (MAPK) signaling cascades in lung epithelial cells in vitro and in vivo. These signaling pathways lead to the enhanced ability of Jun and Fos family members, i.e. components of the activator protein-1 (AP-1) transcription factor, to activate transcription of a number of AP-1-dependent target genes involved in cell proliferation or death, differentiation, and inflammation. Research by the Basbaum laboratory has been critical in showing that mucin transcription in response to cigarette smoke, and gram-positive bacteria is mediated through activation of the epidermal growth factor receptor (EGFR) and MAPK cascades. Work from our laboratories supports the concept that MAPK signaling and AP-1 transactivation by cigarette smoke and asbestos may synergize in lung epithelial cell injury, compensatory proliferation of lung epithelial cells, and carcinogenesis, supporting a mechanistic framework for striking increases in lung cancer in asbestos workers who smoke. Targeting of MAPKs and interrelated signaling cascades may be critical to prevention of lung cancers and control of mucin overproduction in a number of lung diseases including asthma, cystic fibrosis, chronic bronchitis, and chronic obstructive pulmonary disease (COPD).




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