Published ahead of print on September 15, 2006, doi:10.1165/rcmb.2006-0331TR
Am. J. Respir. Cell Mol. Biol., Volume 36, Number 2, February 2007, 158-165
A more recent version of this article appeared on February 1, 2007
Submitted on September 3, 2006
Revised on September 8, 2006
The Role of Heme Oxygenase-1 in Pulmonary Disease
Laura E Fredenburgh1*, Mark A Perrella1, and S. Alex Mitsialis2
1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA,
2 Division of Newborn Medicine, Children's Hospital, Boston, MA, USA
* To whom correspondence should be addressed. E-mail: lfredenburgh{at}partners.org.
Heme oxygenase (HO)-1, the inducible isoform of heme oxygenase, is a cytoprotective enzyme that plays a central role in the defense against oxidative and inflammatory insults in the lung. HO-1 catalyzes the degradation of heme, a potent oxidant, into biliverdin, iron, and carbon monoxide (CO). These downstream products of heme catabolism have recently been found to mediate the anti-oxidant, anti-apoptotic, anti-proliferative, vasodilatory and anti-inflammatory properties of HO-1. While absence of HO-1 is rare in humans, a number of HO-1 promoter polymorphisms have been identified which may influence HO-1 expression in vivo and lead to disease states. This review will summarize studies that implicate HO-1 and heme metabolites in the pathophysiology of pulmonary disease and discuss recent advances in the therapeutic applications of HO-1.
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Copyright © 2006 American Thoracic Society.
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