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Published ahead of print on August 20, 2007, doi:10.1165/rcmb.2007-0198TR

Am. J. Respir. Cell Mol. Biol., Volume 38, Number 2, February 2008, 127-134

A more recent version of this article appeared on February 1, 2008
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Submitted on June 4, 2007
Revised on August 15, 2007

Alveolar Epithelial {beta}2-Adrenergic Receptors

Gokhan M Mutlu1* and Phillip Factor2

1 Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA, 2 Department of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA

* To whom correspondence should be addressed. E-mail: g-mutlu{at}northwestern.edu.

{beta}2-adrenergic receptors are present throughout the lung including the alveolar airspace where they play an important role for regulation of the active Na+ transport needed for clearance of excess fluid out of alveolar airspace. {beta}2-adrenergic receptor signaling is required for upregulation of alveolar epithelial active ion transport in the setting of excess alveolar edema. The positive, protective effects of {beta}2-adrenergic receptor signaling on alveolar active Na+ transport in normal and injured lungs provide substantial support for the use of {beta}2-adrenergic agonists to accelerate alveolar fluid clearance in patients with cardiogenic and non-cardiogenic pulmonary edema. In this review, we summarize the role of {beta}2-adrenergic receptors in the alveolar epithelium with emphasis on their role in regulation of alveolar active Na+ transport in normal and injured lungs.




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