Cover: Inducible nitric oxide synthase (NOS2) expression in nasal and intestinal epithelium from wild-type mice (cftr +/+), mice deficient in cystic fibrosis transmembrane conductance regulator (CFTR) (cftr /), and mice that have had human CFTR introduced to the intestinal epithelium using the fatty acid binding protein (FABP) promoter (FABP-hcftr). Excised nasal epithelium (left panels) and ileum (right panels) were immunostained for NOS2 expression. NOS2 expression in both nasal and ileal epithelium was compared in cftr +/+ (top panels), cftr / (middle panels), and FABP-hcftr (bottom panels) mice. Results are representative of multiple sections taken from three separate cftr +/+ mice, three cftr / mice, and four FABP-hcftr mice. NOS2 expression was visualized with Vector Red ABC stain, and sections were counterstained with hematoxylin. Sections were magnified ×200. For more information, see article by Steagall and colleagues 45.
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