Cover: Upper panel: Gross anatomy of control isograft lungs (A), control allograft lungs (B), and col(V)-fed allograft lungs (C) 2 wk after transplantation (posterior view). The left (L) lung is the transplanted lung and the right (R) is the native lung in each panel. The control allograft lung (L in B) is dark brown in color and shrunken compared with the native lung. However, the col(V)-fed allograft lung (L in C) has the appearance of the isograft lung (L in A). Control isograft lungs (A) show no pathologic lesions and are identical to normal WKY lungs (data not shown). Photographs are representative of five rats in each group. Lower panel: Histology of control isografts (D), control allografts (E), and col(V)-fed allografts (F) 2 wk after transplantation. Control isografts show normal airway and vascular structures (D). Control allografts show extensive perivascular, peribronchial, and alveolar mononuclear cell infiltrates, consistent with severe rejection (E). In contrast, col(V)-fed allografts show only mild to moderate perivascular and peribronchial mononuclear cell infiltrates (F). Photomicrographs are representative of five rats in each group (original magnification: ×100). For more information see article by Yasufuku and colleagues beginning on page 26.
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