Cover: Regulation of m3 mAChR responsiveness upon receptor activation occurs via: (1) receptor modification via phosphorylation by GPCR kinases (GRKs), (2) changes in receptor localization that determine receptor-G protein compartmentalization as well as the kinetics of receptor recycling/degradation that establish levels of cell surface expression, and (3) transcriptional and post-transcriptional mechanisms of receptor synthesis. For more information see Perspective by Billington and Penn beginning on page 269.
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