Tissue distribution of ODN 30 min following intravenous injection of LPD. BrdU-labeled ODN were formulated in LPD composed of DOTAP liposomes and injected into mice at a dose of 25 µg/mouse. At 30 min following injection, mice were killed, lungs were collected, and cryosections were prepared. Detection of BrdU-labeled ODN in lungs was performed. (A) Control lungs of mice receiving nonlabeled ODN. (B) Represenative lung sections of mice receiving BrdU-labeled ODN. (C) Higher magnification of B. (D) Confocal microscopy images of lung sections of mice receiving BrdU-labeled ODN. For more information see article by Ma and colleagues beginning on page 151.