Cover: In the current study, α-tocopherol (α-TOC) provides significant protection from lung injury lung following exposure to lipopolysaccharide (LPS) and correlates with a significant impairment of neutrophil recruitment into the alveolar airspace. The potential mechanisms by which α-TOC confers a protective effect are discussed in the text. These include (i) prevention of neutrophil adhesion by abrogating the expression of adhesion molecules on the surface of endothelial cells and neutrophils; (ii) impaired neutrophil binding to the endothelium due to changes in the topographic distribution or binding affinities of the surface adhesion molecules; and (iii) impaired neutrophil transmigration due to changes in the membrane stability of the migrating neutrophil, the endothelial, and/or the epithelial cell. For more information see Perspective by Chow et al beginning on page 427.