Endogenous expression of CBE1 analyzed by IHC. ALI-differentiated primary epithelial cells, which were treated (J, L, N) or untreated (I, K, M) with IL-13 for 28 d, were also subjected to an immunostaining of CBE1 (I, J), tubulin IV (K, L), or CBE1 plus tubulin IV (M, N). Note strong signals of CBE1 in columnare cells with visible cilia on their apical surface without obvious staining in basal epithelium (I, M), and drastic reduction of staining by IL-13 treatment (J, N). For more information, see article by Yoshisue and colleagues, beginning on page 491.
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