About the cover: Cover is based on a representative image of changes in fura-2 fluorescence signals, an index of intracellular Ca²⁺ concentrations, in the same position after a uniaxial mechanical stretch equivalent to 20% of strain amplitude in HEPES-buffered saline containing 2 mM of Ca²⁺. For more information, see article by Ito and colleagues beginning on page 407.